| 書目名稱 | Drug Delivery in Dermatology | | 副標(biāo)題 | Fundamental and Prac | | 編輯 | Célia Luiza Petersen Vitello Kalil,Valéria Campos | | 視頻video | http://file.papertrans.cn/284/283050/283050.mp4 | | 概述 | Provides practical guidance using simple and straightforward language.Explores several technologies.Discusses a hot topic that is still little explored in Brazil | | 圖書封面 |  | | 描述 | .Skin accounts for approximately 15% of an adult’s total body weight, with a surface of about 2m2. It provides an entry and exit barrier to various substances, offers effective protection against harmful substances, microorganisms and ultraviolet radiation, and is also paramount in immunology and body homeostasis, preventing dehydration and loss of essential minerals..The topical route has a number of advantages over oral and parenteral routes: no first-pass metabolism, greater convenience resulting in better treatment compliance, lower side-effect frequency, and prompt dosing cessation if required. However, the stratum corneum allows penetration of only 1 to 5% of substances applied topically, making this application route much less efficient. Lipophilic and small molecules (up to 500 Da) can cross the stratum corneum, since keratinocytes are covered by a lipid matrix, while it is virtually impossible for hydrophilic and large drugs to cross intact, normal skin, which means that passive topical delivery is restricted. To address this, techniques have been developed aimed at optimizing drug skin penetration by means of chemical, mechanical and physical methods, such as adding perme | | 出版日期 | Book 2021 | | 關(guān)鍵詞 | Laser; Drug Administration; Transepidermal delivery; Microneedling; Microinfusion | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-030-81807-4 | | isbn_softcover | 978-3-030-81809-8 | | isbn_ebook | 978-3-030-81807-4 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
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