Titlebook: Drug Addiction; From Basic Research Rao S. Rapaka,Wolfgang Sadée Book 2008 Springer-Verlag New York 2008 Addiction.Basic.Cannabinoid.Chemo

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Viewing Chemokines as a Third Major System of Communication in the Brainhat products of the immune system, such as chemokines, can reciprocally alter the actions of these drugs and the endogenous ligands for their receptors. Chemokines are a family of small (8 to 12 kDa) proteins involved in cellular migration and intercellular communication. With a few exceptions, they

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Targeting the PDZ Domains of Molecular Scaffolds of Transmembrane Ion Channelsling and maintenance of several receptors and channels. The SAPs consist of 5 individual protein domains: 3 PDZ (PSD95, Disc Large, Zol) domains, an SH3 domain, and an inactive guanyl kinase (GK) domain. The 3 PDZ domains bind the C-termini of specific receptors and channels, leading to the transien

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Role of Monoamine Transporters in Mediating Psychostimulant Effectssposition within the brain. Alterations in DA disposition can lead to conditions such as drug addiction, Parkinson’s disease, and schizophrenia, a fact that underscores the importance of understanding DAergic signaling. Psychostimulants alter DAergic signaling by influencing both DAT and VMAT-2, and

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Serotonin Transporters: Implications for Antidepressant Drug Development disruptions in the serotonergic and noradrenergic systems result in depressive symptoms. Therefore, the serotonin transporter (SERT) has become a pharmacological target for treating these symptoms. This review will discuss what is known about the molecular interactions of antidepressants with SERT.

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κ Opioids as Potential Treatments for Stimulant Dependencerapeutic goal. Classically, the “dopamine hypothesis” has been used to explain the development of addiction and dependence of stimulants. This hypothesis involves the direct increase of dopamine as the major factor in mediating the abuse effects. Therefore, most treatments have focused on directly i