Titlebook: Discovery DMPK Quick Guide; Guide to Data Interp S. Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop Book 2022 Springer Nature Switzerland A

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l for day-to-day interpretation of ADME studies.Multi discip.This book is intended for a broad readership,?in particular,?those working or interested in drug discovery coming from various disciplines such as medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinic

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Goals for DMPK During Drug Optimizations,f a molecule’s interaction/modulation of a therapeutic target. What allows conversion of a potent chemical starting point to a final drug/drug candidate during the optimization process is the incorporation of appropriate ADME properties that balance efficacy and toxicity. Here we capture the high-le

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Drug Properties, (1) an inability to demonstrate that the target can modulate the disease in a preclinical model, (2) the lack of a therapeutic index to modulate the target safely or (3) the inability to find molecules with the right balance of properties such as potency, selectivity, ADME properties, safety endpoi

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DMPK Lead Optimization, optimization of molecules based on key ADME attributes. This has had a huge impact on the molecular design cycles: design, synthesis, assessment and re-design..In this chapter, we discuss the strategies for optimization of small molecules during drug discovery and address various ADME liabilities t