Titlebook: Directed Drug Delivery; A Multidisciplinary Ronald T. Borchardt,Arnold J. Repta,Valentino J. S Book 1985 The Humana Press Inc. 1985 bioche

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Müfit Bahadir,Harun Parlar,Michael Spitellern with unique cell surface determinants was confined largely to immunology groups (Mason and Williams, 1980). As clinical applications appear practical these systems are likely to come increasingly under the purview of pharmacologists. The point of view of this paper is that the questions and tools

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Müfit Bahadir,Harun Parlar,Michael Spitellerry the drug is attached to or associated with a ligand which recognizes a specific receptor on the surface of a target cell. The ligand can be a component of a phospholipid vesicle, e.g. liposome, a lipoprotein particle or a chemical derivative of a macromolecule, small peptide or oligosaccharide (F

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Müfit Bahadir,Harun Parlar,Michael Spitellern. The concept is not new since compounds such as acetylsalicylic acid (aspirin), as a prodrug of salicylic acid, and methenamine, as a prodrug of formaldehyde, were discovered in the late 19th century. The term “pro-drug or “pro-agent” was first used by Albert (1958) who suggested that this approac

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Pharmacodynamic Considerations in the Development of New Drug Delivery Concepts correlations that have been defined, it is important to realize that the relationships are only meaningful at steady state or at a time when the ratio of the drug concentrations at the site of action and in plasma can be expected to remain constant over time; that is, during the terminal log-linear

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Ronald T. Borchardt,Arnold J. Repta,Valentino J. S

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A survey of the experimental situation, correlations that have been defined, it is important to realize that the relationships are only meaningful at steady state or at a time when the ratio of the drug concentrations at the site of action and in plasma can be expected to remain constant over time; that is, during the terminal log-linear

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