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Titlebook: Direct Mechanisms in Cholesterol Modulation of Protein Function; Avia Rosenhouse-Dantsker,Anna N. Bukiya Book 2019 The Editor(s) (if appli

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發(fā)表于 2025-3-21 19:09:48 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Direct Mechanisms in Cholesterol Modulation of Protein Function
編輯Avia Rosenhouse-Dantsker,Anna N. Bukiya
視頻videohttp://file.papertrans.cn/281/280611/280611.mp4
概述Very timely topic as cholesterol, increasingly, has been implicated as a major regulator of protein function.Contributors are well-known experts in their fields and provide international perspective.R
叢書名稱Advances in Experimental Medicine and Biology
圖書封面Titlebook: Direct Mechanisms in Cholesterol Modulation of Protein Function;  Avia Rosenhouse-Dantsker,Anna N. Bukiya Book 2019 The Editor(s) (if appli
描述.In this book, renowned scientists describe how cholesterol interacts with various proteins. Recent progress made in the high-resolution visualization of cholesterol-protein interactions using crystallography and cryogenic electron microscopy has substantially advanced the knowledge of critical features. These features enable specific recognition of the cholesterol molecule by proteins, a process that was built on earlier studies using binding assays, computational modeling and site-directed mutagenesis. ?.Direct Mechanisms in Cholesterol Modulation of Protein Function .offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via direct sensing. Its nine chapters are organized into two distinct parts. In the first part, the chapters introduce the reader to the general characteristics of cholesterol binding sites in proteins. This part starts with a tour into common cholesterol recognition motifs, followed by an overview of the major classes of steroid-binding proteins. It then continues with two chapters that present a comprehensive analysis of molecular and structural characteristics of cholesterol binding sites in transmemb
出版日期Book 2019
關(guān)鍵詞cholesterol modulation; protein function; cholesterol binding; steroid-protein interaction; lipid membra
版次1
doihttps://doi.org/10.1007/978-3-030-14265-0
isbn_softcover978-3-030-14267-4
isbn_ebook978-3-030-14265-0Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl
The information of publication is updating

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沙發(fā)
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板凳
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地板
發(fā)表于 2025-3-22 05:16:52 | 只看該作者
Kleingedrucktes ganz gro? geschriebened by NPC1 and NPC2, and briefly discuss recent findings of cholesterol binding and transport proteins beyond NPC1 and NPC2. We conclude with key questions and major challenges for future research on cholesterol transport by the NPC1 and NPC2 proteins.
5#
發(fā)表于 2025-3-22 12:15:32 | 只看該作者
Crystallographic Studies of Steroid-Protein Interactionsays. Proteins found in some bacteria that bind and metabolize steroids have been investigated as well. A survey of the steroid-protein complexes that have been studied using crystallography and the insight learned from them is presented.
6#
發(fā)表于 2025-3-22 14:38:02 | 只看該作者
Effects of Cholesterol on GPCR Function: Insights from Computational and Experimental Studies complex system in order to shed more light on cholesterol molecular basis of action. The results of molecular simulations that complemented experimental data may reveal new aspects of GPCR-cholesterol interactions and may provide a comprehensive understanding of receptor function.
7#
發(fā)表于 2025-3-22 19:55:19 | 只看該作者
Insights into the Molecular Mechanisms of Cholesterol Binding to the NPC1 and NPC2 Proteinsed by NPC1 and NPC2, and briefly discuss recent findings of cholesterol binding and transport proteins beyond NPC1 and NPC2. We conclude with key questions and major challenges for future research on cholesterol transport by the NPC1 and NPC2 proteins.
8#
發(fā)表于 2025-3-22 23:47:01 | 只看該作者
0065-2598 erts in their fields and provide international perspective.R.In this book, renowned scientists describe how cholesterol interacts with various proteins. Recent progress made in the high-resolution visualization of cholesterol-protein interactions using crystallography and cryogenic electron microsco
9#
發(fā)表于 2025-3-23 03:39:16 | 只看該作者
Philipp Zimmer,Eva Zopf,Freerk Baumannng these effects have remained elusive. There appear to be multiple mechanisms by which cholesterol interacts with proteins. A complete understanding of cholesterol-sensing motifs is still undergoing refinement. Initially, cholesterol was thought to exert only non-specific effects on membrane fluidi
10#
發(fā)表于 2025-3-23 09:33:58 | 只看該作者
Gesamtbetrachtung nach Haushaltsebenen,and intracellular signaling. X-ray crystallography has served as a successful tool for gaining understanding of the structural and mechanistic aspects of these functions by providing snapshots of steroids in complex with various types of proteins. These proteins include nuclear receptors activated b
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