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Titlebook: Dipeptidyl Aminopeptidases; Basic Science and Cl Uwe Lendeckel,Dirk Reinhold,Ute Bank Conference proceedings 2006 The Editor(s) (if applica

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書目名稱Dipeptidyl Aminopeptidases
副標(biāo)題Basic Science and Cl
編輯Uwe Lendeckel,Dirk Reinhold,Ute Bank
視頻videohttp://file.papertrans.cn/281/280552/280552.mp4
概述The first comprehensive volume on Dipeptidyl Aminopeptidases that can be marketed to such a wide variety of disciplines (immunology, autoimmune disease, inflammation, neuroscience, drug development/ph
圖書封面Titlebook: Dipeptidyl Aminopeptidases; Basic Science and Cl Uwe Lendeckel,Dirk Reinhold,Ute Bank Conference proceedings 2006 The Editor(s) (if applica
描述.Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses, and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in the field will contribute to this book, which will present a state-of-the-art view on these enzymes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent. The sections of the book will focus on various topics including DP IV and related enzymes in: expression and function, metabolic disorders, immune mechanisms and immune disorders, neuronal diseases and cancer, and related drug development. .
出版日期Conference proceedings 2006
關(guān)鍵詞Diabetes; Diabetes mellitus; autoimmunity; clinical application; enzymes; infectious diseases; metabolic d
版次1
doihttps://doi.org/10.1007/0-387-32824-6
isbn_softcover978-1-4614-9769-1
isbn_ebook978-0-387-32824-9
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines
The information of publication is updating

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沙發(fā)
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板凳
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地板
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Dipeptidyl Peptidase 8 Has Post-Proline Dipeptidyl Aminopeptidase and Prolyl Endopeptidase Activitiewere inhibited by the irreversible DPIV inhibitor ValboroPro. These data indicate that DP8 is a multifunctional enzyme and that therapeutics based on DPIV inhibition should be counter-screened against DP8.
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Species of Aphytis of the World HN digestion. Consequently, PEP-inhibition might be a new target for apoptosis prevention..This study further uncovered a so far unknown enzymatic specificity for a post-cysteine cleavage of the mammalian exopeptidases DP2, DP4, DP8 and DP9 and the endopeptidase PEP.
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發(fā)表于 2025-3-23 01:34:53 | 只看該作者
Ekaterina Isaeva,Olga Baiburovar with DPIV to make a model based on two enzymatically active proteins. Simulated docking of substrates and inhibitors into the model may uncover subtle differences between the structures. This may aid in determining the reason for DP8’s multiple enzyme functionality and aid in the improvement of DPIV inhibitor specificity.
10#
發(fā)表于 2025-3-23 06:13:44 | 只看該作者
Michael F. Allen,Brent D. Mishlerific inhibition of DPIV and AAPs via small molecular compounds provides a new approach for the pharmacological treatment of autoimmune and inflammatory diseases that simultaneously interferes with two major axis of T cell function.
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