Titlebook: Diagnoses Without Names; Challenges for Medic Michael D. Lockshin,Mary K. Crow,Medha Barbhaiya Book 2022 Springer Nature Switzerland AG 202

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Ever-Evolving Disease Classification Criteria for Clinical Trials and Studies: The Case of Systemic ue patient, classification and classification criteria are used to describe populations for clinical trials and studies and to create somewhat homogeneous, reproducible, and understood populations for clinical research. The development of classification criteria with high sensitivity and specificity

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FIS

When the Illness Has No Name: Focus on Clinical Trials in Systemic Lupus Erythematosusrials, especially those with oversight by regulatory agencies, are pure, they are not. Systemic lupus erythematosus (SLE) clinical trials suffer from some of the same issues that plague everyday clinical life. Does everyone in a clinical trial truly have SLE? Is the activity score declared in the ca

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Managing and Tolerating Diagnostic Uncertaintyfor managing diagnostic uncertainty, however, this pursuit is inadequate. Diagnostic knowledge takes time to acquire, and diagnostic uncertainty is not completely curable. Furthermore, diagnostic uncertainty elicits negative psychological responses that need to be palliated, as well as positive resp

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Carminative

In the Box or Out of the Boxtudies in well-defined population. Inclusion and exclusion criteria may be the most important aspect of a clinical study or trial. Lumping or splitting determines which patients can ultimately use a risk stratification algorithm or a therapy. Both processes are valid; studies must be more transparent about how they have lumped or split.

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