Titlebook: Diabetic Renal-Retinal Syndrome; 21st Century Managem Eli A. Friedman (Distinguished Teaching Professor) Book 1998 Springer Science+Busines

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A new hypothesis on mechanisms of retinal vascular permeability in diabetes,associates provide evidence that retinal hemorrhages, lipid exudate deposition, and macular edema result from aberrant production of vasoactive agents. Candidate vasoactive factors include histamine and vascular endothelial growth factor/vascular permeability factor (VEGF/VPF). Either or both of the

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Surgical management of proliferative diabetic retinopathy,med vitrectomy, when indicated, adds a further surgical intervention in the struggle to preserve sight in diabetes. Charles emphasizes the distinction between a need for immediate surgery in traction retinal detachment involving the macula, neovascular glaucoma, and anterior vitreous cortex fibro-va

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Xenotransplantation of encapsulated porcine islets,d for survival on insulin of xenogeneic origin (pigs and cows) from Banting and Best’s first report in 1922 until the introduction of recombinant human insulin in the 1980s. A logical though until now impossible extension of the use of xenogeneic cell products is direct implantation of living xenoge

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Generation of non-immunogenic islet cells using genetic engineering,to date in this’ star Wars’ level research. By inserting an immortalized cell line with no potential for malignant mutagenesis, murine β-cells from transgenic mice expressing a rat insulin promoter-driven immortalizing gene plus an internal suicide gene were synthesized. Brownlee envisions combinati

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Insulin-independence for > 10 years in 32 pancreas transplant recipients from an historical era,lar complications in type 1 diabetes is a allogeneic pancreas transplant. True, the surgery is difficult mandating long hospital stays. Also, when compared with a kidney transplant alone, both morbidity and mortality are greater in recipients of a combined pancreas and kidney transplant. Najarian re

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