| 書目名稱 | Diabetes and Protein Glycosylation | | 副標(biāo)題 | Measurement and Biol | | 編輯 | Margo Panush Cohen | | 視頻video | http://file.papertrans.cn/271/270424/270424.mp4 | | 圖書封面 |  | | 描述 | In the years since the initial discovery that blood from diabetic patients contains increased amounts of a posttranslationally gluco- sylated form of hemoglobin (hemoglobin Ale)‘ an impressive number of studies have clarified and expanded the use of glycohemoglobin levels to assess disease status. Many other structural proteins have been shown to undergo similar changes, including proteins from tissues most commonly affected in diabetes (e.g., lens, aorta, peripheral nerve, basement membrane). Thus, the nonenzymatic glycosylation of hemoglobin emerges as an invaluable model for the pathogenesis of certain chronic diabetes complications. In addition to reviewing a wealth of investigative possibilities in the area of these chronic complications-including eye, kidney, nerve, and vascular disease-Dr. Cohen indicates how enhanced nonenzymatic glycosylation in uncontrolled diabetes underscores the pressing need for maintenance of long-term euglycemia. Dr. Cohen is an endocrinologist and diabetes specialist whose research activities have largely focused on the chemistry and metabo- lism of the basement membrane in diabetes. This superb monograph on nonenzymatic glycosylation clearly shows | | 出版日期 | Book 1986 | | 關(guān)鍵詞 | Diabetes; G proteins; Monosaccharid; enzymes; proteins; tissue; translation; metabolic disease | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4612-4938-2 | | isbn_softcover | 978-1-4612-9366-8 | | isbn_ebook | 978-1-4612-4938-2 | | copyright | Springer-Verlag New York Inc. 1986 |
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