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Titlebook: Developmental Toxicology; Methods and Protocol Craig Harris,Jason M. Hansen Book 2012 Springer Science+Business Media, LLC 2012 antioxidant

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發(fā)表于 2025-3-21 18:56:59 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Developmental Toxicology
副標(biāo)題Methods and Protocol
編輯Craig Harris,Jason M. Hansen
視頻videohttp://file.papertrans.cn/271/270115/270115.mp4
概述Highlights the evolution of methods from classical teratology approaches to the dynamic, state-of-the-art molecular methods.Provides step-by-step detail essential for reproducible results.Contains key
叢書名稱Methods in Molecular Biology
圖書封面Titlebook: Developmental Toxicology; Methods and Protocol Craig Harris,Jason M. Hansen Book 2012 Springer Science+Business Media, LLC 2012 antioxidant
描述.The discipline of developmental toxicology is an integration of concepts, models, and methodologies based heavily on the superimposition of toxicology principles upon the science of developmental biology.? The science of developmental toxicology also borrows from other research areas that are concerned with regulation of cell growth, migration, differentiation and cell death, as such are central to the study of stem cells, cancer, and chronic diseases. In .Developmental Toxicology: Methods and Protocols. expert researchers in the field detail many of the methods which are now commonly used to study developmental toxicology highlighting the evolution of methods from classical teratology approaches to the dynamic, state-of-the-art molecular methods, systems biology, and next generation models and procedures. Written in the highly successful .Methods in Molecular Biology?. series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls..?.Authoritative and practical, .Developmental Toxicology: Methods and Protoco
出版日期Book 2012
關(guān)鍵詞antioxidant; biotransformation of chemicals; cell death; cell growth; developmental toxicology; embryogen
版次1
doihttps://doi.org/10.1007/978-1-61779-867-2
isbn_softcover978-1-4939-6207-5
isbn_ebook978-1-61779-867-2Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightSpringer Science+Business Media, LLC 2012
The information of publication is updating

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發(fā)表于 2025-3-22 00:10:35 | 只看該作者
In Vivo Models of Developmental Toxicology,d at a sufficient dosage during a sensitive period of development in a sensitive species. While in vitro approaches in developmental toxicology can provide a means to assess the potency of toxicants, ultimately, the need to use whole animal models to demonstrate embryotoxicity is necessary to fully
板凳
發(fā)表于 2025-3-22 00:29:59 | 只看該作者
, as a Model in Developmental Toxicology,ng with conservation of disease and stress response pathways, availability of mutant and transgenic strains, and wealth of biological information, have led to the increased use of . in toxicological studies. Although the potential to study the mechanisms of developmental toxicology in . is promising
地板
發(fā)表于 2025-3-22 08:12:53 | 只看該作者
Zebrafish Embryo Developmental Toxicology Assay,y is approximately 87% in AB strain fish (Brannen KC et al., Birth Defects Res B Dev Reprod Toxicol 89:66–77, 2010). The procedure entails exposing dechorionated gastrulation-stage embryos to a range of compound concentrations for 5 days throughout embryonic and larva development. The larvae are eva
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發(fā)表于 2025-3-22 12:25:45 | 只看該作者
Gene Knockdown by Morpholino-Modified Oligonucleotides in the Zebrafish (,) Model: Applications forany advantages of zebrafish include their small size, prolific spawning, rapid development, and transparent embryos. They can be easily manipulated genetically through the use of transgenic technology and gene knockdown via morpholino-modified antisense oligonucleotides (MOs). Knocking down specific
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發(fā)表于 2025-3-22 15:08:22 | 只看該作者
An Amphibian Model for Studies of Developmental Reproductive Toxicity,ces of early life-stage exposure to endocrine disrupting chemicals. The African clawed frog . has several characteristics which facilitates studies of developmental reproductive toxicity. Here, I present a . test protocol, including study design, exposure regime, and endpoints for chemical disruptio
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發(fā)表于 2025-3-22 19:12:38 | 只看該作者
Avian Models in Teratology and Developmental Toxicology,plant culture. Like mammals, avian embryos have an allantois and their developmental pathways are highly conserved with those of mammals, thus avian models have biomedical relevance. Fertile eggs are inexpensive and the embryo develops rapidly, allowing for high-throughput. The chick genome is seque
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發(fā)表于 2025-3-22 22:06:56 | 只看該作者
Primary Cell and Micromass Culture in Assessing Developmental Toxicity,of which was reproductive/developmental toxicity. Thousands of chemicals will need testing which will require a large number of laboratory animals. In vitro systems (as pre-screens or as validated alternatives) appear to be useful tools to reduce the number of whole animals used or refine procedures
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發(fā)表于 2025-3-23 01:33:30 | 只看該作者
Embryonic Stem Cell Test: Stem Cell Use in Predicting Developmental Cardiotoxicity and Osteotoxicit With appropriate toxicity data sets, acceptable exposure levels and actual safety of prescription and nonprescription drugs as well as environmental chemicals could be established for individuals that are more vulnerable to chemical exposure, such as pregnant women and their unborn children. The ga
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發(fā)表于 2025-3-23 07:37:48 | 只看該作者
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