Titlebook: Developmental Aspects of the Lymphatic Vascular System; Friedemann Kiefer,Stefan Schulte-Merker Book 2014 The Editor(s) (if applicable) an

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Applications of differentiation,e present classification system, which, however, is the basis for the choice of optimal patient care. Non-syndrome and syndrome types of primary lymphedema are presented in detail and related molecular findings are summarized.

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Plasticity of Airway Lymphatics in Development and Disease,atics in the respiratory tract undergo rapid changes around birth, during adaptation to air breathing, when lymphatic endothelial cells develop button-like intercellular junctions specialized for efficient fluid uptake and transport. In inflammatory conditions, lymphatic vessels proliferate and unde

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Regulation of Lymphatic Vasculature by Extracellular Matrix,ties. In addition to providing structural support to tissues, it regulates a variety of cellular responses during development and tissue homeostasis. Interactions between the lymphatic vessels and their ECM are starting to be recognized as important modulators of lymphangiogenesis. Here, we review t

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Development of Secondary Lymphoid Organs in Relation to Lymphatic Vasculature,nt of lymphatic vessels and lymph nodes occurs within the same embryonic time frame. Specification of lymphatic endothelial cells starts around embryonic day 10 (E10), followed by endothelial cell budding and formation of the first lymphatic structures. Through lymphatic endothelial cell sprouting t

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