| 書目名稱 | Development of Selective DNA-Interacting Ligands | | 副標(biāo)題 | Understanding the Fu | | 編輯 | Sefan Asamitsu | | 視頻video | http://file.papertrans.cn/270/269999/269999.mp4 | | 概述 | Nominated as an outstanding Ph.D. thesis by Kyoto University.Includes systematic and exhaustive reviews of non-canonical DNA structures.Offers extensive information on the synthesis of molecules, in a | | 叢書名稱 | Springer Theses | | 圖書封面 |  | | 描述 | This book addresses the development of both DNA-sequence-selective and DNA-form-selective ligands, with the aim of creating potential molecular probes and therapeutic agents for non-canonical DNA structure-caused human diseases.??.Over the past two decades, the structural diversity of DNA forms has been proven to have profound implications in various biological, neurological, and pharmacological events. In response, researchers have since made tremendous efforts to obtain highly active drugs interacting with disease-related non-canonical DNA structures. These drugs, however, have not yet been approved for clinical use. One obstacle impeding their clinical application has to do with selectivity.? ?.This book focuses on secondary DNA structures formed by trinucleotide repeat sequences (“hairpin form”) or guanine-rich sequences (“G-quadruplex form”), both of which are pathological molecules for neurodegenerative diseases and/or cancer. Most importantly, it contends that a particular secondary structure of DNA in the context of the human genome can be targeted with a minimal affinity to other DNA structures by means ofcareful and rational ligand design. This approach opens an avenue to | | 出版日期 | Book 2020 | | 關(guān)鍵詞 | Non-canonical DNA Structure; Trinucleotide Repeat; G-quadruplex; Synthetic Ligand; Rational Ligand Desig | | 版次 | 1 | | doi | https://doi.org/10.1007/978-981-15-7716-1 | | isbn_softcover | 978-981-15-7718-5 | | isbn_ebook | 978-981-15-7716-1Series ISSN 2190-5053 Series E-ISSN 2190-5061 | | issn_series | 2190-5053 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapor |
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