| 書目名稱 | Design, Analysis, and Interpretation of Genome-Wide Association Scans | | 編輯 | Daniel O. Stram | | 視頻video | http://file.papertrans.cn/269/268802/268802.mp4 | | 概述 | Ushers in future with GWAS studies as a more routine part of clinical trials of drugs, drug combination therapy and a part of the general goal of seeking personalized medicine.Does not require previou | | 叢書名稱 | Statistics for Biology and Health | | 圖書封面 |  | | 描述 | .This book presents the statistical aspects of designing, analyzing and interpreting the results of genome-wide association scans (GWAS studies) for genetic causes of disease using unrelated subjects. Particular detail is given to the practical aspects of employing the bioinformatics and data handling methods necessary to prepare data for statistical analysis. The goal in writing this book is to give statisticians, epidemiologists, and students in these fields the tools to design a powerful genome-wide study based on current technology. The other part of this is showing readers how to conduct analysis of the created study..Design and Analysis of Genome-Wide Association Studies provides a compendium of well-established statistical methods based upon single SNP associations. It also provides an introduction to more advanced statistical methods and issues. Knowing that technology, for instance large scale SNP arrays, is quickly changing, this text has significant lessons for future use with sequencing data. Emphasis on statistical concepts that apply to the problem of finding disease associations irrespective of the technology ensures its future applications. The author includes curre | | 出版日期 | Book 2014 | | 關(guān)鍵詞 | Biostatistics; GWAS studies; Genetic disease variation; Genome studies; Risk prediction; Statistics in pu | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4614-9443-0 | | isbn_softcover | 978-1-4939-4952-6 | | isbn_ebook | 978-1-4614-9443-0Series ISSN 1431-8776 Series E-ISSN 2197-5671 | | issn_series | 1431-8776 | | copyright | Springer Science+Business Media New York 2014 |
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