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Titlebook: Deoxynucleoside Analogs in Cancer Therapy; Godefridus J. Peters (Professor of Medical Oncolog Book 2006 Humana Press 2006 HIV.cancer.cance

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樓主: TIBIA
51#
發(fā)表于 2025-3-30 11:29:02 | 只看該作者
Beanspruchung stabf?rmiger Bauteile 5-fluorodeoxyuridine, possibly because MRP8 can efflux the monophosphate derivative of these analogs. However, the affinity of these transporters for the nucleotide analogs studied thus far is relatively low (millimolar rather than micromolar), and this limits their potential impact on resistance.
52#
發(fā)表于 2025-3-30 16:17:13 | 只看該作者
Karl-Heinrich Grote,J?rg Feldhusenent injection or by continuous infusion over 5–10 d. The presence of drug refractoriness and relapsing leukemia together with insights into the mechanisms of ara-C resistance led to the development of high-dose (1–3 g/m.) ara-C treatment. A number of different strategies have been developed to incre
53#
發(fā)表于 2025-3-30 16:34:57 | 只看該作者
Beanspruchung stabf?rmiger Bauteilevirus infections, and several other analogs, such as clevudine and troxacitabine, are in advanced clinical trial development stages. Among these, troxacitabine, a true chain terminator, is the first L-nucleoside endowed with promising antitumor activity against leukemia as well as solid tumors. This
54#
發(fā)表于 2025-3-30 22:25:40 | 只看該作者
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