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Titlebook: Delta Opioid Receptor Pharmacology and Therapeutic Applications; Emily M. Jutkiewicz Book 2018 Springer International Publishing AG, part

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書(shū)目名稱(chēng)Delta Opioid Receptor Pharmacology and Therapeutic Applications
編輯Emily M. Jutkiewicz
視頻videohttp://file.papertrans.cn/266/265015/265015.mp4
概述Discusses emerging knowledge about the biological function of the delta opioid receptor.Describes therapeutic potential of the delta opioid receptor system.Describes unique trafficking and signaling p
叢書(shū)名稱(chēng)Handbook of Experimental Pharmacology
圖書(shū)封面Titlebook: Delta Opioid Receptor Pharmacology and Therapeutic Applications; Emily M. Jutkiewicz Book 2018 Springer International Publishing AG, part
描述This volume describes our current understanding of the biological role of the delta-opioid receptor (DOR) system, focusing on its unique mechanisms of receptor trafficking and signaling in disease states. Part 1 covers the endogenous ligands that regulate the DOR system as well as novel compounds and therapies used to modulate the DOR system. Part 2 describes new insights into the localization and trafficking of the DOR and how ligand-directed signaling alters the fate of the receptor. Part 3 concentrates on the potential role of the DOR system in disease states, such as pain, mood, addiction, and Parkinson’s disease. Throughout the book, the DOR system as a target for drug development will be discussed.
出版日期Book 2018
關(guān)鍵詞CNS-related diseases; Enkephalin; biased agonism; drug development; pain, emotion and addiction; receptor
版次1
doihttps://doi.org/10.1007/978-3-319-95133-1
isbn_softcover978-3-030-06980-3
isbn_ebook978-3-319-95133-1Series ISSN 0171-2004 Series E-ISSN 1865-0325
issn_series 0171-2004
copyrightSpringer International Publishing AG, part of Springer Nature 2018
The information of publication is updating

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Multifunctional Opioid Ligands,the treatment of many different conditions, including pain, depression, and addiction. However, stimulation or blockade of any one opioid receptor type often leads to on-target adverse effects that limit the clinical utility of a selective opioid agonist or antagonist. Literature precedent suggests
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Delta Opioid Receptor Expression and Function in Primary Afferent Somatosensory Neurons, somatosensory experiences, from shooting pain to pleasant touch. In recent years, the identification of dozens of genetic markers specifically expressed by subpopulations of DRG neurons has dramatically improved our understanding of this diversity and provided the tools to manipulate their activity
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Delta Opioid Receptors and Modulation of Mood and Emotion,gh opioids have long been known to regulate mood states, the use of opioids to treat depression is rarely discussed. This chapter explores the preclinical and clinical evidence supporting the antidepressant-like effects of opioid ligands, and in particular, delta opioid receptor (DOR) agonists. DOR
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