Titlebook: Delayed Preconditioning and Adaptive Cardioprotection; G. F. Baxter,D. M. Yellon Book 1998 Springer Science+Business Media Dordrecht 1998

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Einkommen- und K?rperschaftsteuerhe first observation that elevated temperature could trigger rapid and specific changes in chromosomal and metabolic activity of living organisms; new mRNA was synthesised within 2–3 minutes [1, 2]. During the 1970s several laboratories discovered that novel (heat shock) proteins were expressed in c

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https://doi.org/10.1007/978-3-322-99076-1, heat stress [2], endotoxin [3], and cytokines [4,5]. The classic preconditioning phenomenon, in which brief, nonlethal ischaemia, rapidly increases the tolerance of the heart to subsequent lethal ischaemia, has been observed in experimental models [1] and in patients [6,7]. The mechanism of classi

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Die Gemeinde und ihr Territoriumt isolation and perfusion in the Langendorff mode resulted in an enhanced post-ischaemic recovery of myocardial function (left ventricular developed pressure, + dP/dt) and an increase in catalase activity. Hearts isolated from rats which were pretreated with LPS for only 1 hour did not have an incre

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https://doi.org/10.1007/978-3-322-99003-7ns of adenosine have been appreciated for many years (see reference 1 for review). It is known that various forms of myocardial stress, including ischaemia, hypoxia or catecholamines, result in a rapid increase in extracellular levels of adenosine. This in turn results in activation of local adenosi

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https://doi.org/10.1007/978-3-642-47013-4ary endothelium determines arrhythmia severity following coronary artery occlusion and whether this plays a role in ischaemic preconditioning. In this chapter, we describe the protection against ventricular arrhythmias afforded by preconditioning, with particular emphasis on the delayed form of protection.

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Book 199893, two reports heralded the recognitionof a delayed preconditioning response in the heart, now commonly knownas the `second window‘ of protection. Since then, a number of studieshave described the ability of delayed preconditioning and relatedadaptive phenomena to protect against a variety of patho

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