Titlebook: Deep Brain Stimulation; A New Frontier in Ps Damiaan Denys,Matthijs Feenstra,Rick Schuurman Book 2012 Springer-Verlag Berlin Heidelberg 201

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Mustererkennung (Pattern-Recognition)rders. However, the mode of action of DBS is still unclear. It is unknown which neural cell types in the complex brain circuitry are involved in the workings of DBS, and how high-frequency stimulation of specific cell types may lead to the alleviation of a patient’s clinical symptoms. Although the e

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978-3-642-43470-9Springer-Verlag Berlin Heidelberg 2012

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Deep Brain Stimulation of the Human Reward System as a Putative Treatment for Refractory Major Deprs (Cg.) with the NAc—has recently been proposed as new hypothesis-driven target awaiting clinical evidence. The application of NAc DBS for the treatment of bipolar disorder and other psychiatric diseases (e.g., alcohol dependency, opioid addiction, schizophrenia) is currently being investigated. No

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Manipulating Addictive Behaviour in Animal Models,of otherwise refractory drug dependence, animal models can help to define the optimal brain target for DBS and provide useful insights into the neurobiological mechanisms underlying the beneficial effects of DBS treatment. In this chapter, we discuss the validity of animal models of addiction and pr

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