Titlebook: Damage-Associated Molecular Patterns in Human Diseases; Volume 1: Injury-Ind Walter Gottlieb Land Book 2018 Springer International Publishi

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Prologue: The Term “Immunity” over the Course of Time disease 2000?years ago up to the description of the self/nonself discrimination theory in immunology in the mid-1990s. Originally, the term was mainly employed by non-physicians and understood as a passive exemption from diseases provoked by gods or demons. After the introduction of “variolation” a

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Epilogue: What Major Paradigm in Immunology Comes Next?few reflections, and insinuated in relation to the history of other discoveries in medicine in general. In particular, the growing notion is discussed that the discovery of DAMP-promoted innate/adaptive immune events has not only led to a change of view in immunology but is going to lead to a comple

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Innate Immune Recognition Moleculesthem with the unique property to sense and respond to any cell stress/tissue injury, be it of infectious or sterile nature. The process is based on the recognition of conserved structures of microbes known as microbe-molecular patterns or pathogen-associated molecular patterns and stress/injury-indu

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Prologue: The Whole Body as an?Immune Systemroader sense. According to new notions, these cells can be divided into groups of mobile/circulating innate immune cells and sessile/resident innate immune cells. This new insight into the plethora of body cells operating as recognition molecule-bearing cells of the innate immune system has contribu