Titlebook: Damage-Associated Molecular Patterns in Human Diseases; Volume 1: Injury-Ind Walter Gottlieb Land Book 2018 Springer International Publishi

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bizarre

Mobile Innate Immune Cells of natural killer cells and unconventional T cells, all properties aimed at getting rid of inciting insults and restoring homeostasis. Another striking feature of these mobile innate immune cells is their role in preparing a robust adaptive immune response upon the presence of nonself or altered-se

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Sessile Innate Immune Cellsssues, thereby playing a crucial role in tissue repair processes. Vascular cells of the innate immune system represent an evolutionarily developed first-line defense against any inciting insult hitting the vessel walls from the luminal side including bacteria, viruses, microbial toxins, and chemical

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Epilogue : Cells of Our Immune System: A Whole Army of Defenders Far Beyond T and B Cells eliminate the harmful agent and to repair and remodel the injured tissue. However, if the injury is too heavy or becomes chronically repetitive or even persistent, the response may turn into an uncontrolled, exaggerated, or overshooting reaction and, thus, may lead to pathologies and diseases. In t

FATAL

Prologue: About DAMPs, PAMPs, and MAMPs produced by previously DAMP-activated stressed or dying cells; and (4) exogenous DAMPs. These categories are subdivided into 11 classes of DAMPs, which are further sorted into (altogether) 37 subclasses, predominantly according to their biochemical nature and different functions. In addition, the t

Meander

Endogenous DAMPs, Category I: Constitutively Expressed, Native Molecules (Cat. I DAMPs) I refers to molecules, which are exposed on the surface of stressed cells. They include the subclass of phagocytosis-facilitating molecules such as calreticulin, as well as the subclass of MHC-I-related molecules such as MHC-I-related molecule A and B. These DAMPs are capable of inducing the activa

含糊

Endogenous DAMPs, Category II: Constitutively Expressed, Injury-Modified Molecules (Cat. II DAMPs)dified DAMPs. Subclasses include nuclear DNA breaks, cytosolic mislocated/dislocated nuclear and mitochondrial DNA, cytosolic abnormally accumulating RNA, dyshomeostasis-associated perturbed molecular patterns such as reflected by intracellular potassium efflux, and accumulating metabolic molecules

綁架

Endogenous DAMPs, Category III: Inducible DAMPs (Cat. III DAMPs)odies, and galectins. Prominent candidates of modified molecules include actively secreted, processed interleukin-1 family members, processed high mobility group box 1, and anaphylatoxins. Subgroups of SAMPs refer to molecules known to contribute not to promotion but to resolution of inflammation. T