Titlebook: DNA-Encoded Chemical Libraries; Methods and Protocol David Israel,Yun Ding Book 2022 Springer Science+Business Media, LLC, part of Springer

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書目名稱DNA-Encoded Chemical Libraries影響因子(影響力)




書目名稱DNA-Encoded Chemical Libraries影響因子(影響力)學(xué)科排名




書目名稱DNA-Encoded Chemical Libraries網(wǎng)絡(luò)公開度




書目名稱DNA-Encoded Chemical Libraries網(wǎng)絡(luò)公開度學(xué)科排名




書目名稱DNA-Encoded Chemical Libraries被引頻次




書目名稱DNA-Encoded Chemical Libraries被引頻次學(xué)科排名




書目名稱DNA-Encoded Chemical Libraries年度引用




書目名稱DNA-Encoded Chemical Libraries年度引用學(xué)科排名




書目名稱DNA-Encoded Chemical Libraries讀者反饋




書目名稱DNA-Encoded Chemical Libraries讀者反饋學(xué)科排名

潛伏期

Library Synthesis: Building Block Validation,nsuring the quality of a library. Here we describe the validation method used to assess the reactivity of potential building blocks to be included in a DNA-encoded library, with HATU acylation of carboxylic acid building blocks with an on-DNA amine substrate as an example.

Congestion

Library Synthesis and Analytics,to billions of compounds can be prepared by a combination of chemical and enzymatic synthesis. Here we describe the analytics methods used in the library synthesis with one cycle of synthesis as an example.

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cultivated

DNA-Compatible Nitro Reduction and Synthesis of Benzimidazoles,rary structure diversity is often limited to DNA-compatible chemical reactions in aqueous media. Herein, we describe a facile process for reducing aryl nitro groups to aryl amines by using sodium dithionite (Na.S.O.). The new protocol offers simple operation and circumvents the pyrophoric potential

cultivated

DNA Encoding of Natural Products,mbinatorial synthesis. Natural products (NPs) are evolutionary optimized compounds that have played a key role in the history of human drug discovery. Herein, we describe a method for functionality-independent annotation of complex natural products with amplifiable DNA barcodes to generate a DNA-enc

違反

Isthmus

One Bead-One Compound (OBOC) Peptidomimetic-Encoded Library Synthesis via Split-and-Pool Methods, of therapeutically important compounds with higher affinity and improved pharmacological properties against different protein targets..Here we describe a simple and general method for the submonomer solid phase synthesis of large one bead-one compound (OBOC) peptidomimetic libraries of structurally

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DNA Conjugates as Tool Compounds for DEL Selections,e ligand that binds to the target protein can be conjugated to DNA to mimic compounds contained in DEL libraries. The conjugate can be used as a ligand in preselection binding assays to validate a target protein and optimize selection methods and serve as a positive control in selection experiments.