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Titlebook: DNA Vaccines; Methods and Protocol Douglas B. Lowrie,Robert G. Whalen Book 2000 Springer Science+Business Media New York 2000

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發(fā)表于 2025-3-21 16:57:44 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱DNA Vaccines
副標(biāo)題Methods and Protocol
編輯Douglas B. Lowrie,Robert G. Whalen
視頻videohttp://file.papertrans.cn/261/260211/260211.mp4
叢書名稱Methods in Molecular Medicine
圖書封面Titlebook: DNA Vaccines; Methods and Protocol Douglas B. Lowrie,Robert G. Whalen Book 2000 Springer Science+Business Media New York 2000
描述The field of DNA vaccines has undergone explosive growth in the last few years. As usual, some historical precursors of this approach can be d- cerned in the scientific literature of the last decades. However, the present state of affairs appears to date from observations made discreetly in 1988 by Wolff, Malone, Felgner, and colleagues, which were described in a 1989 patent and published in 1990. Quite surprisingly, they showed that genes carried by pure plasmid DNA and injected in a saline solution, hence the epithet “naked DNA,” could be taken up and expressed by skeletal muscle cells with a low but reproducible frequency. Such a simple methodology was sure to spawn many applications. In a separate and important line of experimentation, Tang, De Vit, and Johnston announced in 1992 that it was indeed possible to obtain humoral immune responses against proteins encoded by DNA delivered to the skin by a biolistic device, which has colloquially become known as the “gene gun. ” The year 1993 saw the publication of further improvements in the me- ods of naked DNA delivery and, above all, the first demonstrations by several groups of the induction of humoral and cytotoxic immune respon
出版日期Book 2000
版次1
doihttps://doi.org/10.1385/1592596886
isbn_softcover978-1-4899-4182-4
isbn_ebook978-1-59259-688-1Series ISSN 1543-1894 Series E-ISSN 1940-6037
issn_series 1543-1894
copyrightSpringer Science+Business Media New York 2000
The information of publication is updating

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沙發(fā)
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On Automatic Design of Neuro-fuzzy Systemsonkeys (.), . in mice (.,.), malaria in mice (.,.), and genital herpes simplex virus in guinea pigs (.). Recently, DNA vaccines for the protection against influenza (Merck Research Laboratories, Rahway, NJ), malaria (Vical Inc., San Diego, CA), and HIV (Apollon Inc., Philadelphia, PA), have entered
地板
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Ana Starcevic,Boris Vucinic,Ilona Karpiel’s cells and induce expression of the transgene. Moreover, immunization with purified TAA peptides or with antigen-presenting cells, such as dendritic cells, pulsed with TAA peptides have been proposed.
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Ashlesha Kumar,Kuldip Singh Sangwan,Dhiraj IL-12 and IFN-γ, with little secretion of Th2 cytokines (.,.). These effects can also be obtained with synthetic oligonucleotides (ODN) (.,.) or plasmid DNA vectors (.) containing CpG immunostimulatory motifs. From a teleological view, it appears likely that the rapid immune activation in response
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Artificial Intelligence and Soft Computing7 [.–.], and GM-CSF [.,.]), chemokines (TCA-3 [.], RANTES [.], MIP-1 [.]), and costimulatory molecules (CD40L [.], B7-1 [.] and B7-2 [.]) could enhance or modify the specific immune responses elicited by DNA immunization (. .).
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發(fā)表于 2025-3-22 23:52:14 | 只看該作者
Development and Characterization of Lyophilized DNA Vaccine Formulations,onkeys (.), . in mice (.,.), malaria in mice (.,.), and genital herpes simplex virus in guinea pigs (.). Recently, DNA vaccines for the protection against influenza (Merck Research Laboratories, Rahway, NJ), malaria (Vical Inc., San Diego, CA), and HIV (Apollon Inc., Philadelphia, PA), have entered
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