Titlebook: DNA Topoisomerases in Cancer Therapy; Present and Future Toshiwo Andoh Book 2003 Springer Science+Business Media New York 2003 DNA.biology.

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Mechanism of action of topoisomerase II-targeted anticancer drugs,A scission. Considering the importance of topoisomerase II-targeted agents to cancer chemotherapy, it is essential to understand how these drugs alter enzyme function. Therefore, this review will focus on the DNA cleavage and ligation reactions of topoisomerase II and the mechanism of action of drug

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clinical development as a useful and important reference book for students and researchers in the field of pharmacology, toxicology, oncology and molecular biology. .978-1-4613-4941-9978-1-4615-0141-1

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