Titlebook: DNA Topoisomerases in Cancer Therapy; Present and Future Toshiwo Andoh Book 2003 Springer Science+Business Media New York 2003 DNA.biology.

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Gunay Kazimzade,Yasmin Patzer,Niels Pinkwartecin was found clinically active but was discontinued in the 70’s because of severe side effects and lack of understanding of the drug’s mechanism of action. The finding in 1985 that top1 was the target of camptothecin generated great interest to find water-soluble, more efficacious and less toxic a

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Seungcheol Austin Lee,Yuhua (Jake) Liange dynamics. Two types of enzymes, type I and II, are validated targets of a number of efficacious anticancer drugs. Doxorubicin, etoposide, amsacrine and mitoxantrone are among others are frequently prescribed drugs targeting type II enzyme, topo II. There have been enormous efforts in search for ne

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https://doi.org/10.1007/978-1-4615-0141-1DNA; biology; cancer; cell; cell death; enzyme; enzymes; molecular biology; pharmacology; protein; resistance;

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Reflections on an accidental discovery,arrival as an assistant professor of chemistry. The country in general, and Berkeley in particular, was under the dark shadow of the Vietnam War. There were frequent demonstrations on campus, and once the campus was teargassed by a helicopter. For weeks a “stink bomb” left a repugnant smell in our e

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Mechanisms of topoisomerase I inhibition by anticancer drugs, salt of camptothecin was found to be clinically active but its use was discontinued in the 70’s because of severe side effects and lack of understanding of the drug’s mechanism of action (5). The finding in 1985 that camptothecin specifically poisons top1 has generated great interest to find water-

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Mechanism of action of topoisomerase II-targeted anticancer drugs,ess and is required for proper chromosomal structure and segregation. The enzyme unknots and untangles DNA by passing an intact helix through a transient double-stranded break that it generates in a separate DNA segment. Beyond its physiological functions, topoisomerase II is the target for some of