Titlebook: DNA Repair of Cancer Stem Cells; Lesley A Mathews,Stephanie M Cabarcas,Elaine M. Hu Book 2013 Springer Science+Business Media Dordrecht 20

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Learning from Others’ Experienceype of somatic cell and play essential roles during development, whereas multipotent stem cells produce a limited number of closely related cell types and are responsible for tissue homeostasis during an organism’s lifetime. It is essential for stem cells to maintain genomic integrity, as alteration

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https://doi.org/10.1007/978-3-642-02956-1ce is the recent appreciation for a cellular hierarchy within the tumor bulk with only a subpopulation of cells, termed cancer stem cells, able to reinitiate tumor growth in transplantation assays. With the identification of these cells comes a further complexity in our consideration of how the hete

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https://doi.org/10.1007/978-3-642-02956-1CSC have stem cell properties. The maintenance and propaganda of BCSC is controlled by an intrinsic stem cell signaling network and regulated by extrinsic environmental factors. BCSC are resistant to chemotherapy and radiation therapy. The therapeutic resistance of BCSC derives from multiple mechani

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Social Learning and Pricing Obfuscationhis disease. There is evidence to indicate that pancreatic cancer is initiated and propagated by cancer stem cell (CSC)s. The CSC population is defined by its tumor initiating capacity and has been shown to be invasive or metastatic. Loss of genome stability is a hallmark of cancer with DNA repair e

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Andrea Teglio,Marco Raberto,Silvano Cincottious characterization of tumor cells has lead to an abundance of data supporting the existence of cell populations with stem cell characteristics, including self-renewal and expression of stem cell markers. There is also evidence suggesting that these cells are responsible for chemo- and radio-resist

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Artificial Economics and Self Organization of cancer biology. The molecular mechanism(s) which this specific subpopulation of cells utilize to sustain themselves is currently under investigation. Recent studies demonstrate that CSCs express enhanced DNA repair mechanisms which can contribute to their ability to evade traditional cancer trea

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Introduction to Cancer Stem Cells,Cs). CSCs are thought to be at the apex of a cellular hierarchy, where they are capable of differentiating into the other cells found within a tumor. They may also be responsible for both patient relapse due to their relative resistance to chemotherapy as well as metastasis. In recent years, much re

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