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Titlebook: DNA Repair of Cancer Stem Cells; Lesley A Mathews,Stephanie M Cabarcas,Elaine M. Hu Book 2013 Springer Science+Business Media Dordrecht 20

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發(fā)表于 2025-3-21 16:54:24 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱DNA Repair of Cancer Stem Cells
編輯Lesley A Mathews,Stephanie M Cabarcas,Elaine M. Hu
視頻videohttp://file.papertrans.cn/261/260186/260186.mp4
概述Currently there are no books solely available on DNA repair mechanisms and Cancer Stem Cells.This information can be used by academic institutions, pharmaceutical companies, medical professionals, gov
圖書封面Titlebook: DNA Repair of Cancer Stem Cells; Lesley A Mathews,Stephanie M Cabarcas,Elaine M. Hu Book 2013 Springer Science+Business Media Dordrecht 20
描述The existence of ‘cancer stem cells’ (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to metastasis and patient demise. To help aid clinicians, pharmaceutical companies and academic labs investigating how to better kill these highly aggressive cells we have summarized the DNA repair mechanism(s) and their role in the maintenance and regulation of both normal and cancer stem cells. Our book represents a comprehensive investigation into the highly effective DNA repair mechanisms of CSCs and what we need to understand in order to develop more advanced therapies to eradicate them from patients. Currently, there are no other published works entirely on DNA repair and Cancer Stem Cells. In addition, our book provides a comprehensive overview of CSC isolation and characterization from a variety of solid tumor types.
出版日期Book 2013
關(guān)鍵詞Cancer Stem Cells; DNA Repair; Drug Resistance; Tumor Initiating Cells; qHTS Screening
版次1
doihttps://doi.org/10.1007/978-94-007-4590-2
isbn_softcover978-94-007-9705-5
isbn_ebook978-94-007-4590-2
copyrightSpringer Science+Business Media Dordrecht 2013
The information of publication is updating

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DNA Repair Mechanisms in Glioblastoma Cancer Stem Cells, on the cellular response to DNA damage to elicit their therapeutic benefit. For GSCs, the field is just beginning to appreciate how these cells respond on a molecular level to DNA damage. Nonetheless, advances have been made that highlight novel modes of potential therapeutic intervention and under
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DNA Repair Mechanisms in Other Cancer Stem Cell Models,been seen in hematopoietic stem cells from different species and at different developmental stages. Furthermore cell cycle and metabolic states of stem cells seem to affect choices of DNA repair pathways and a choice between cell survival and death.
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Patterns for Expert-Novice Chatllular signaling pathways (Fig.?3.1). A better understanding of these resistance pathways is a necessary prerequisite towards the ultimate goal of developing novel strategies specifically targeting CSCs. Better designed therapies could ultimately reverse their resistance and thereby eliminate the po
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Learning from Others’ Experienceuch as low mitochondrial activity and reactive oxygen species (ROS) production, high activity of efflux pumps, expression of telomerase, efficient DNA repair, as well as triggering apoptosis at a lower threshold than other cell types. Quiescence of multipotent stem cells may minimize chances of accu
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