Titlebook: DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells; Muriel W. Lambert,Jacques Laval Book 1989 Springer Science+Bus

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S. F. He,J.-Y. Wei,C. Eyzaguirregle and tandem double base pair substitutions with no preference for a particular type of change, although the GC ? CG transversion was not detected. Mutations in V-H1 cells consisted of single and tandem double base pair changes, which were all GC ? AT transitions, and frame shift mutations. The as

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Structure-Function Relationships in Alkylation Damage and Repairn be either mutagenic or lethal. Most recently, in order to separate the potential biological effects of each derivative, defined oligonucleotide sequences containing a single adduct have been synthesized and used to study both replication and mutation. These defined oligomers have also been of grea

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The Mer Minus Phenotype, Patient Response to Nitrosoureas, and Protooncogene Activation in Human Gli MNNG or nitrosoureas (Day, ., 1980a,b; Erickson, 1980a,b; Scudiero, ., 1984 a,b; Gibson, ., 1986). The results obtained in cell culture are clear-cut; for example, with MNNG as the damaging agent, the inactivation slopes of survival curves of Mer. cells are up to 50 fold steeper than are those of M

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An Update of the Mammalian UV Response: Gene Regulation and Induction of a Protective Functionon analyses supplied support for the idea that proneness to mutation is passed on to daughter cells (Maher, ., 1988). As another parallel between bacteria and mammalian cells DNA damage causes reinitiation of replication (Kogoma, ., 1979) which in mammalian cells is observed as gene amplification (L

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Molecular Studies of Mutagenesis using Plasmid Vectors in Xeroderma Pigmentosum Cellsated that dimers are the major mutagenic lesions. The major UV photoproduct, the TT dimer, was only weakly mutagenic in these human cells. Most mutations occured at cytosines that were 3′ to a cytosine or a thymine. There was a restricted spectrum of UV induced mutations with XP-A and XP-D cells: Pl