Titlebook: DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells; Muriel W. Lambert,Jacques Laval Book 1989 Springer Science+Bus

Corporeal

The Roles of Beta- and Delta-Eliminations in the Repair of AP Sites in DNAicipate in the excision of AP sites. In fact, we know a single class of AP endonucleases; these enzymes hydrolyze the C.-O-P bond 5′ to AP sites and the resulting nicks are limited by 3′-OH and 5′-phosphate ends.

BULLY

Inducible Repair in Mammalian Cells Treated with Alkylating Agentse promutagenic lesion O.-methylguanine, is the product of the . gene. It regulates its own synthesis and the expression of the . A gene (Teo, ., 1986) which encodes DNA glycosylase II: this enzyme removes several alkylated bases and especially the toxic lesions 3-methyl-adenine and 3-methylguanine from alkylated DNA (Karran, ., 1982).

eulogize

Towards a Role for Promutagenic Lesions in Carcinogenesiscal properties of these compounds. Until recently, it has not been possible to begin to confirm the relevance of such observations for human disease, but techniques now permit preliminary studies of these potentially initiating events in human tissues.

軍火

襲擊

DNA Damage and Oxygen Speciestive damage to DNA (both base and sugar damage). Yet, the nature and relative rates of the reactions involving active oxygen species make it difficult to ascertain, in each particular situation, what reactants may act as the predominant genotoxicant and what DNA repair mechanisms may ensue.

Boycott

Art, Spirituality and EconomicsWhen DNA is exposed to alkylating agents, reactions occur at as many as fifteen different sites on the bases and at the phosphodiester backbone (Beranek, ., 1980). The relative proportion of the alkylation products depends mainly on the nucleophilicity of the reactive sites and on the chemical properties of the alkylating agents (Lawley, 1974).

小蟲(chóng)

escalate

The Role of O6-Alkylguanine in Cell Killing and Sister Chromatid Exchange Induced by Alkylating AgenWhen DNA is exposed to alkylating agents, reactions occur at as many as fifteen different sites on the bases and at the phosphodiester backbone (Beranek, ., 1980). The relative proportion of the alkylation products depends mainly on the nucleophilicity of the reactive sites and on the chemical properties of the alkylating agents (Lawley, 1974).

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