Titlebook: DNA Helicases and DNA Motor Proteins; Maria Spies Book 2013 The Editor(s) (if applicable) and The Author(s), under exclusive license to Sp

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Structure and Mechanisms of SF1 DNA Helicases, involved in essential processes in both DNA and RNA metabolism in all organisms. In addition to conserved amino acid sequences, they also share a common structure containing two RecA-like motifs involved in ATP binding and hydrolysis and nucleic acid binding and unwinding. Unwinding is facilitated

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Structure and Mechanisms of SF2 DNA Helicases,ons that constitute these processes. Many of these machines use single-stranded nucleic acids as templates, and their actions are often regulated by the participation of nucleic acids in multimeric structures and macromolecular assemblies that restrict access to chemical information. Superfamily II

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RecQ Helicases: Conserved Guardians of Genomic Integrity,RecQ family members have been identified: BLM, WRN, RECQ4, RECQ1 and RECQ5. Defects in three of these give rise to Bloom’s syndrome (BLM), Werner’s syndrome (WRN) and Rothmund–Thomson/RAPADILINO/Baller–Gerold (RECQ4) syndromes. These syndromes are characterised by cancer predisposition and/or premat

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