| 書目名稱 | Cytochrome P450 Protocols | | 編輯 | Ian R. Phillips,Elizabeth A. Shephard,Paul R. Orti | | 視頻video | http://file.papertrans.cn/243/242616/242616.mp4 | | 概述 | Includes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts.Includes supplementary materia | | 叢書名稱 | Methods in Molecular Biology | | 圖書封面 |  | | 描述 | .Cytochromes P450 (CYPs) comprise a large superfamily of proteins that are of central importance in the detoxification or activation of a tremendous number of natural and synthetic hydrophobic xenobiotics, including many therapeutic drugs, chemical carcinogens and environmental pollutants. CYPs are important in mediating interactions between an organism and its chemical environment and in the regulation of physiological processes. .Cytochrome P450 Protocols, Third Edition .focuses on high-throughput methods for the simultaneous analysis of multiple CYPs, substrates or ligands. Although the emphasis is on CYPs of mammalian origin, it reflects an increasing interest in CYPs of bacterial species. Also included are chapters on cytochrome P450 reductase (the redox partner of CYPs) and the flavin-containing monooxygenases (FMOs), and metabolomic and lipidomic approaches for identification of endogenous substrates of CYPs (‘de-orphanizing’ CYP substrates). Written in the successful .Methods in Molecular Biology?. series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes o | | 出版日期 | Book 2013Latest edition | | 關(guān)鍵詞 | CYP enzymes; Cytochrome P450 enzymes; DNA shuffling; LC-MS; mass spectrometry | | 版次 | 3 | | doi | https://doi.org/10.1007/978-1-62703-321-3 | | isbn_softcover | 978-1-4939-6269-3 | | isbn_ebook | 978-1-62703-321-3Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Springer Science+Business Media New York 2013 |
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