Titlebook: Cytochrome P450 Protocols; Ian R. Phillips,Elizabeth A. Shephard Book 19981st edition Springer Science+Business Media New York 1998

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Fluid Management in COVID-19 ICU Patients9 protein expression can be increased in cells treated with a P450 inducer such as phenobarbital, dexamethasone, or rlfampin (rifampicin) (.). This is consistent with the clmical finding that rlfampin increases the total body clearance of tolbutamide (.), which is metabolized almost entirely by hepa

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Precision Medicine in Septic Shockher CYP2C8 or CYP2C9 (.). Considerable interindividual differences occur in hepatic CYP2C19 content (., .), primarily owmg to a genetic polymorphism in this enzyme (4). Approximately 15-20% of Orientals and 3% of Caucasians exhibit the CYP2C19 poor-metabolizer phenotype, which is associated with at

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P. Eggimann,Y. -A. Que,F. Venturasulting in a substantially reduced capacity to metabolize a large number of clinically useful drugs, including metoprolol, propafenone, haloperrdol, dextromethorphan and codeine (.). Quinidine competrtively inhibits CYP2D6, with a K. of 3-30 m. (.–.). Because of its preferential inhibition of CYP2D6

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O. Turgman,M. Schinkel,W. J. Wiersingacultures of human hepatocytes with ethanol induces CYP2E1 protein (.) and this is consistent with the finding that hepatic CYP2El protein (.) and mRNA (.) amounts are increased in alcoholics. Although only a few drugs (e.g., acetaminophen [.]) have been identified as substrates for CYP2E1, many low

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A. Abdalla,K. Dhaliwal,M. Shankar-Haris expressed in human fetal liver (.). The CYP3A enzymes account for an estimated ~30% of total human cytochrome P450 content in adult liver (.), although large inter-individual differences exist in hepatic CYP3A content. CYP3A4 is present in all adult human livers and is inducible by drugs such as r

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Coral Spawning Behavior and Timing4All mRNA is present in greater abundance in kidney than in liver, whereas it is absent in lung (.). Various fatty acids, including lauric acid (.–.), are substrates for recombinant CYP4Al l. Experiments with a panel of individual cDNA-expressed P450 enzymes indicate that CYP4Al l is a major lauric

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Purification of Cytochromes P450: Products of Bacterial Recombinant Expression Systems,plasmid expressed (NF14) are presented elsewhere (., .). The general procedure can be utilized for other cytochromes P450, with some modification, as described elsewhere (., .–.). Several general purification techniques are described in detarl in Chapters 4 and 5 of this volume.

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Springer Science+Business Media New York 1998