Titlebook: Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism; Aparajita Dey Book 2013 Springer Science+Business Media Dordrecht 2013 Cytoc

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Relevance of CYP2E1 to Non-alcoholic Fatty Liver Disease,ignificance was not achieved because of small sample sizes. Some more indirect data also suggests a relationship between high CYP2E1 activity and progression to NASH. However, three recent genome-wide association studies on NAFLD have failed to find any evidence that single nucleotide polymorphisms

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The Role of Cytochrome P450 2E1 in Ethanol-Mediated Carcinogenesis,ch an induction in the mucosa of the small intestine and the colon. The overall induction of CYP2E1 shows interindividual variations and occurs already following a daily ingestion of 40 g of ethanol after 1 week. CYP2E1 induction is associated with an increased metabolism of ethanol resulting in the

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Relevance of CYP2E1 to Non-alcoholic Fatty Liver Disease,. Increased hepatic expression of CYP2E1, which carries out omega hydroxylation of fatty acids, was first shown in a mouse model of NASH and this was later also reported for human NASH, though not all studies agree with this finding and further larger studies are still needed. In view of its role in

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