Titlebook: Cyclosporin; Mode of Action and C Angus W. Thomson (Reader in Immunology) Book 1989 Kluwer Academic Publishers 1989 T cell.bone marrow.cell

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The 1720s: Radical Change and Controversies,ty and nephrotoxicity.. Two female patients were reported to have slight increase in facial and limb hair, all seven patients had elevated levels of serum bilirubin and alkaline phosphatase, and serum creatinine was elevated in all, with four having unexplained primary oligo-anuria. The authors stat

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Inhibitory effects of cyclosporin A on lymphocyte activation,fungi . and . that showed strong . immunosuppressive activity in micer but was otherwise well tolerated. Their influential publication on the properties of CsA in 1976. led to successful clinical trials, and the drug is now in routine use in organ transplantation. It also shows promise in the preven

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Effect of cyclosporin A on the immune response: pivotal role of the interleukin-2/ interleukin-2 re cell-mediated immune responses.. Within a decade of these initial observations CsA has become the front-line immunosuppressive agent to prevent solid organ graft rejection and graft-versus-host disease in clinical transplantation.. Its usefulness is currently being evaluated in a wide variety of au

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The influence of cyclosporin A on T cell activation, cytokine gene expression and cell-mediated imm Borel . (1976) of the immunosuppressive properties of the drug. It was clear from such early publications that CsA exerted a powerful and selective inhibitory action against T lymphocytes. Whilst the capacity of CsA to abrogate the activation of CD4. (T helper/inducer) lymphocytes and the secretion

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ingenue

Prevention of graft rejection by cyclosporin A in man, rejection was first recognized, attempts have been made to modify the host response to foreign antigens in order to prevent rejection and possibly engender graft tolerance — a state in which the graft is no longer recognized as foreign by the host This ideal is not yet possible in clinical practice

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Cyclosporin A and bone marrow transplantation,t disease (GVHD) by inducing graft—host tolerance was reported.. It has been shown to be effective in minimizing both the incidence of GVHD and marrow graft rejection. Both these complications of marrow transplantation are mediated by T cells, the former by those in the infused donor marrow and the

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