Titlebook: Cycloadditions in Bioorthogonal Chemistry; Milan Vrabel,Thomas Carell Book 2016 The Editor(s) (if applicable) and The Author(s), under exc

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2367-4067 ished and emerging topics in modern chemical research.Superv.The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with re

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Aneurysmen der thorakalen Aortaof CuAAC reaction as a prominent bioorthogonal reaction, discuss various ligands used in reducing Cu(I) toxicity while promoting the reaction rate, and illustrate some of its important biological applications. The development of additional transition metals in catalyzing cycloaddition reactions will also be briefly introduced.

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Transition-Metal-Catalyzed Bioorthogonal Cycloaddition Reactions,of CuAAC reaction as a prominent bioorthogonal reaction, discuss various ligands used in reducing Cu(I) toxicity while promoting the reaction rate, and illustrate some of its important biological applications. The development of additional transition metals in catalyzing cycloaddition reactions will also be briefly introduced.

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Aneurysmen der thorakalen Aortang with the main synthetic strategies to prepare cycloalkynes and their chemical reactivities. Core aspects of the strain-promoted reaction of cycloalkynes with azides are covered, as well as tools to achieve further reaction acceleration by means of modulation of cycloalkyne structure, nature of az

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Aneurysmen der thorakalen Aortabroad utility in biological systems. We discuss in each cases the chemical and mechanistic background, the kinetics of the reactions and the biological applicability together with the limiting factors.

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