Titlebook: Chemistry and Biology of O-GlcNAcylation; Wen Yi Book 2024 The Editor(s) (if applicable) and The Author(s), under exclusive license to Spr

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Vladi Kolici,Yi Liu,Leonard Barolliproteins, shows significant roles in a variety of biological processes, such as signal transduction, transcriptional regulation, stress response, apoptosis, and cellular signaling and metabolism. Moreover, O-GlcNAcylations with abnormal expression levels have proven to be closely associated with man

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https://doi.org/10.1007/978-3-030-02607-3 we will focus on its role on transcription. We will first review new methodologies to study chromatin-bound .-GlcNAcylated proteins. Then we will venture into different organisms, including flies, humans, and plants, and summarize the role of OGT in transcription. In flies, we will emphasize the ro

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Fatos Xhafa,Santi Caballé,Leonard Barollit protein O-GlcNAcylation underlies the initiation and progression of multiple human diseases, such as cancer. Herein, we summarized our current understanding of protein O-GlcNAcylation and signal transduction pathway in cancer. In brief, we discuss O-GlcNAcylated proteins in some canonical oncogeni

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Advances on Smart and Soft Computingl and pluripotency. These two properties are intricately regulated through complex mechanisms during early embryogenesis and development. Recent evidence has shown that O-GlcNAcylation plays a pivotal role in regulating stem cell identity and cell fate decision. Here, we summarize key developments i

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Talal Almutiri,Faisal Saeed,Manar Alassaf can be removed by O-GlcNAcase (Oga), and is abundant in the neuronal system. Ogt modifies a variety of proteins and regulates multiple biological processes during embryonic and postnatal neurogenesis, neuronal development, and brain function. Previous studies have shown that the dysregulation of O-

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