Titlebook: Cutaneous Drug Eruptions; Diagnosis, Histopath John C. Hall,Brian J. Hall Book 2015 Springer-Verlag London 2015 Allergy.Dermatology Drugs.D

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Drug-Induced Photosensitivity sunburn and can occur in anyone exposed to sufficient amounts of the offending drug and adequate wavelengths of radiation. Photoallergy is a type IV delayed hypersensitivity reaction that presents as an eczematous eruption in someone who has previously been sensitized to the drug. A focused history

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Erythema Nodosum as a Drug Eruptionmany conditions including infections (viral, bacterial, fungal, protozoal), pregnancy, medications, autoimmune conditions, and malignancies. Half of all cases are idiopathic. Associated medications that are known to cause EN include oral contraceptive pills (OCPs), sulfonamides, penicillin, bromides

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Lichen Planus Drug Reactionsix Ps: planar (flat-topped), purple, polygonal, pruritic, papules, and plaques. These characteristic lesions are often covered by the lacy, reticular, white lines known as Wickham striae. The exact etiology of this disease is unknown, however an immune- mediated pathology is well documented in the l

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Pityriasis Rosea-Like Drug Eruptionsce of a salmon-pink oval patch or plaque deemed the “herald patch.” This is followed by the widespread eruption of oval macules, papules, and plaques whose long axis follows the lines of cleavage, resulting in the characteristic “Christmas tree” or “fir tree” distribution. A skin eruption very simil

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Psoriasiform Drug Eruptions and Drugs That Flare Psoriasispitate de novo psoriasis in patients irrespective of a family history of psoriasis. The clinical spectrum includes limited or generalized erythematous plaques with thick, large, silvery scales, pustular lesions, or erythroderma. Histopathological examination demonstrates psoriasiform epidermal hyper

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Acne and Drug Reactionsles, cysts, and scarring of varying severity. Factors which promote the development of acne are: increased sebum production, which is influenced by endogenous androgens; ductal hypercornification; abnormal follicular keratinization; colonization of the pilosebaceous ducts by .; inflammation; and gen

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Collagen Vascular Diseases and Cutaneous Drug Reactionstructural proteins, primarily collagen, as foreign, resulting in self-directed immune responses. Tissues composed of various forms of collagen are often affected, including arteries, tendons, and other connective tissues. For this reason, CVD is sometimes called connective-tissue disease. Environmen

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Fixed Drug Eruptionsey may be solitary, multiple, or generalized. The initial eruption of a FDE appears 1 week post-drug exposure, whereas subsequent exposures to the same drug lead to development of lesions within 30 min to 24 h. Despite the number of occurrences, these patches and plaques resolve within 2–3 weeks of

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