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Titlebook: Cushing’s Syndrome; Dorothy T. Krieger Book 1982 Springer-Verlag Berlin, Heidelberg 1982 ACTH.Cushing-Syndrom.Gonadotropin.aldosterone.bio

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發(fā)表于 2025-3-21 17:44:57 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Cushing’s Syndrome
編輯Dorothy T. Krieger
視頻videohttp://file.papertrans.cn/242/241564/241564.mp4
叢書名稱Monographs on Endocrinology
圖書封面Titlebook: Cushing’s Syndrome;  Dorothy T. Krieger Book 1982 Springer-Verlag Berlin, Heidelberg 1982 ACTH.Cushing-Syndrom.Gonadotropin.aldosterone.bio
描述The unraveling of our knowledge of the functions of the adrenal gland constitutes one exciting development of modern medicine and biochemistry. We owe these advances to the felicitous cooperative efforts of the clinical investigator and the biochemist. Three centuries elapsed between the first recorded anatomical descrip- tion of the adrenals and the demonstration by Dr. Addison in the mid-nineteenth century of the fatal results of the destruction of these glands by disease. It became evident from this observation that the adrenals secreted a "factor" or "factors" essential to life. It took approximately 90 years to isolate this elusive vital factor - cortisone - from beef adrenal cortices, independently by both Reichstein and his co-workers in Basle and Kendall and his group in the United States and another 10-15 years before it became more generally available for experimental and clinical use. It is perhaps difficult to believe that as recently as 35-40 years ago, before cortisone and cortisol were clinically available, the surgical removal of a benign adrenal cortical tumor in patients with Cushing‘s syndrome was associated with a prohibitive postoperative mortality rate. Within
出版日期Book 1982
關(guān)鍵詞ACTH; Cushing-Syndrom; Gonadotropin; aldosterone; biosynthesis; glucocorticoid; growth; growth hormone; horm
版次1
doihttps://doi.org/10.1007/978-3-642-81659-8
isbn_softcover978-3-642-81661-1
isbn_ebook978-3-642-81659-8Series ISSN 0077-1015
issn_series 0077-1015
copyrightSpringer-Verlag Berlin, Heidelberg 1982
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沙發(fā)
發(fā)表于 2025-3-21 23:25:58 | 只看該作者
,Laboratory Diagnosis of Cushing’s Disease and Syndrome,ish those who may have suggestive signs and symptoms, but may prove to be eucorticoid, from those patients who actually have increased corticosteroid production. In the latter group, it is further necessary to distinguish patients with Cushing’s disease from those with either adrenal or ectopic ACTH-producing tumors.
板凳
發(fā)表于 2025-3-22 01:52:02 | 只看該作者
地板
發(fā)表于 2025-3-22 05:47:38 | 只看該作者
A Commentary on the Poems of Thomas Hardyish those who may have suggestive signs and symptoms, but may prove to be eucorticoid, from those patients who actually have increased corticosteroid production. In the latter group, it is further necessary to distinguish patients with Cushing’s disease from those with either adrenal or ectopic ACTH-producing tumors.
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發(fā)表于 2025-3-22 10:41:23 | 只看該作者
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發(fā)表于 2025-3-22 13:59:07 | 只看該作者
Michael Robartes and the Dancermulates the adrenal cortex in vertebrate animals and man. The N-terminal 24 amino acids are identical in all species studied. Minor species differences in amino acid composition occur in the 25–39 portion of the molecule. On a molar basis, the 1–24 amino acid sequence of the ACTH molecule possesses
7#
發(fā)表于 2025-3-22 19:36:11 | 只看該作者
https://doi.org/10.1007/978-1-349-00163-7structural sequences for these actions and the mechanisms by which they produce their effects. Most of the structure-function relationships have dealt with the steroidogenic activity of ACTH (Hofmann 1974; Schwyzer 1977). The concept has evolved that there are sequences which comprise the “active” o
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發(fā)表于 2025-3-23 01:13:59 | 只看該作者
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發(fā)表于 2025-3-23 02:50:19 | 只看該作者
https://doi.org/10.1007/978-1-349-00163-7of ACTH is the predominant form identified in the pituitary, except for a variable fraction (previously termed big ACTH) eluting in the void volume, which represents approximately 15 %–25 % of the total ACTH content (Gewirtz and Yalow 1974; Orth and Nicholson 1977). Since at the time of these studie
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發(fā)表于 2025-3-23 07:06:30 | 只看該作者
https://doi.org/10.1007/978-1-349-00163-7me that will enable clinical distinctions to be made among the various subgroups. For this reason, greatest emphasis in this chapter will be placed on the pathophysiology of Cushing’s disease, since the clinical findings associated with this condition are seen in virtually all other causes of Cushin
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