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Titlebook: Current Advances in Osteosarcoma; Eugenie S. Kleinerman, M.D. Book 20141st edition Springer Nature Switzerland AG 2014 bone cancer.cancer.

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發(fā)表于 2025-3-21 19:35:30 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Current Advances in Osteosarcoma
編輯Eugenie S. Kleinerman, M.D.
視頻videohttp://file.papertrans.cn/242/241113/241113.mp4
概述The topics provide a starting block for unified discussions for osteosarcoma researchers in order to move the field forward.The volume editor is an internationally recognized leader in the field of sa
叢書名稱Advances in Experimental Medicine and Biology
圖書封面Titlebook: Current Advances in Osteosarcoma; Eugenie S. Kleinerman, M.D. Book 20141st edition Springer Nature Switzerland AG 2014 bone cancer.cancer.
描述.Current Advances in Osteosarcoma edited by Dr. Eugenie S. Kleinerman summarizes molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and it is also the most common histological form of bone cancer.?It accounts for approximately 56% of new bone tumors, making it the most primary malignant bone tumor in children and adolescents. The lungs are the most common site of metastases and once osteosarcoma spreads to the lungs, it is very difficult to treat. To improve the outcome of this disease, the biology of osteosarcoma needs to be better understood. There are numerous investigators around the world who have made seminal discoveries about the important molecular pathways and genetic alterations that contribute to the development and metastases of osteosarcoma. Other investigators have proposed?novel therapeutic strategies including some based on the molecular and genetic phenotype of the disease. Current Advances in Osteosarcoma summarizes all of these new discoveries in one singular text, which?will?help?move the field?forward..
出版日期Book 20141st edition
關鍵詞bone cancer; cancer; metastasis; osteosarcoma; pediatric cancer
版次1
doihttps://doi.org/10.1007/978-3-319-04843-7
isbn_softcover978-3-319-34459-1
isbn_ebook978-3-319-04843-7Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightSpringer Nature Switzerland AG 2014
The information of publication is updating

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發(fā)表于 2025-3-21 22:19:11 | 只看該作者
Wnt Signaling in Osteosarcomaonal co-activator β-catenin, which ultimately controls key developmental gene expressions. Given the central role of this mediator, inhibition of Wnt/β-catenin signaling has been investigated as a potential strategy for cancer control. In OS, several secreted protein families modulate the Wnt/β-cate
板凳
發(fā)表于 2025-3-22 01:45:05 | 只看該作者
Receptor Tyrosine Kinases in Osteosarcoma: Not Just the Usual Suspectse then validated using independent validation experiments. From these results, we identified four RTKs (Axl, EphB2, FGFR2, and Ret) that have not been previously studied in osteosarcoma and provide targets for the development of novel therapeutics.
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Developmental Pathways Hijacked by OsteosarcomaThis pathway also helps regulate expression of the mature osteoblast protein osteocalcin. YAP also regulates expression of MT1-MMP, a membrane-bound matrix metalloprotease responsible for remodeling the extracellular matrix surrounding the osteoblasts. YAP, in turn, can be regulated by the ERBB fami
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Role of Ezrin in Osteosarcoma Metastasis protein that associated with OS and other cancers. Ezrin is the prototypical ERM (Ezrin/Radixin/Moesin) protein family member. ERMs function as linker proteins connecting the actin cytoskeleton and the plasma membrane. Since our initial identification of ezrin in pediatric sarcoma, an increasing un
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Using Canine Osteosarcoma as a Model to Assess Efficacy of Novel Therapies: Can Old Dogs Teach Us Nethout chemotherapy that could not be done in humans with osteosarcoma due to ethical concerns. This chapter will focus on the novel therapies in the dog that have been reported or are in veterinary clinical trials at the author’s institution. It is hoped that collaboration between veterinary oncolog
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