Titlebook: Crohn‘s Disease and Ulcerative Colitis; From Epidemiology an Daniel C. Baumgart Book 2017Latest edition Springer International Publishing A

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Immunobiology of T-Cells in Inflammatory Bowel Diseasespecific methods by which they have been generated. In murine models, a qualitative or quantitative defect in regulatory T cells can lead to colitis development, but there does not appear to be an obvious defect in regulatory T cell number or function in inflammatory bowel diseases. Effector and reg

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Matrix Metalloproteinasesstromelysin 2) and MMP-11; matrilysins, including MMP-7 and MMP-26; macrophage metalloelastase (MMP-12) [4]. The majority of MMPs are released into the ECM, whereas membrane-bound (MT)-MMPs are activated intracellularly by furin and subsequently anchored to the cell surface by a transmembrane domain

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Mouse Models of Chronic Intestinal Inflammation: Characterization and Use in Pharmacological Intervegly appreciated that the mouse immune system differs substantially from that of humans, and thus, may not express the same pathogenetic mechanisms that are thought to occur in human IBD. This chapter presents a critical evaluation of selected mouse models of IBD and discusses their utility in precli