Titlebook: Critical Issues in Head and Neck Oncology; Key Concepts from th Jan B. Vermorken,Volker Budach,Brian O‘Sullivan Conference proceedings‘‘‘‘‘

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Gregor Domes,Beate Ditzen,Jürgen Bartheal, nasopharyngeal, sinonasal, periorbital, and salivary gland cancer. The limited broad availability of this treatment method and its unknown cost-effectiveness need to be evaluated. In this chapter, we discuss the currently available evidence of PT for HNCs and viable options to generate further

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Entscheidungen vor dem Schreiben,rboplatin with or without 5-fluorouracil, taxanes or cetuximab). However, none of these have shown superior results over the use of cisplatin in randomized trials. Late toxicity is a major downside of CCRT, and this is most worrying for those with the highest chance of cure, i.e. low-risk human papi

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, overall survival following SBRT-based reirradiation remains moderate, which might be due to insufficient doses. There is thus a need for well-designed trials of SBRT-based reirradiation in terms of dose escalation and combination with systemic therapy. In HNC, the evidence for treatment of oligome

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,Elektra: Des ?dipus geistige Schwester,ent in most cases, along with radiotherapy and chemotherapy. Biotherapy and immunotherapy are only anecdotally and compassionately used. For each histology, a careful selection of modalities and their timing is paramount to ensure the best chance of cure. In keeping with the principles of precision

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Zaher Jandali,Klaus Müller,Lucian Jigaonent in the multidisciplinary management of MiSGMTs, and its possible use should be considered. For selected naso-ethmoidal MiSGMTs, especially adenoid cystic carcinoma of the ethmoid, small case series have supported the use of endoscopic transnasal surgery. Similarly, it has been shown that MiSGM

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Immune Checkpoint Inhibition and Radiotherapy in Head and Neck Squamous Cell Carcinoma: Synergisms l researchers currently aims at the development and evaluation of combined modality treatment approaches. Radiotherapy is a highly promising partner in this regard and represents a crucial treatment modality for patients with locally advanced HNSCC. Historically established as cytotoxic anti-cancer

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How to Standardize Molecular Profiling Programs for Routine Patient Care,nical judgement. All steps described above are not standardized, resulting in relevant heterogeneity in treatment recommendations among MTBs in different institutions..In this chapter, contemporary challenges will be discussed, including intratumoral heterogeneity, use of diverse molecular diagnosti