Titlebook: Continuous Dopaminergic Stimulation in Parkinson’s Disease; Proceedings of the W J. A. Obeso,R. Horowski,C. D. Marsden Conference proceedin

Glower

https://doi.org/10.1007/978-3-322-80731-1infusion together with a small dose of levodopa (plus DDI) are effective treatment for “on-off” fluctuations in Parkinson’s disease, but the frequency of adverse effects limits the number of patients who can be treated successfully with this technique.

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獨(dú)白

Continuous subcutaneous lisuride infusions in Parkinson’s diseaseinfusion together with a small dose of levodopa (plus DDI) are effective treatment for “on-off” fluctuations in Parkinson’s disease, but the frequency of adverse effects limits the number of patients who can be treated successfully with this technique.

不可思議

Pharmacokinetics of lisuride after subcutaneous infusiontion of the infusion, concentrations declined with a half-life of 1.4 ± 0.4 hour. The total clearance of lisuride was 20 ± 6 ml/min/kg. Due to the low interpatient variability of plasma levels, a good control of clinical effects is to be expected.

BOOM

Lisuride infusion pump in Parkinson’s disease. A report of two casesough a net increase in the number of hours spent “on”. Dyskinesias remained unmodified. Limiting psychiatric side effects were observed in one of the patients..Practical and technical aspects of the management of this therapeutic method are discussed.

cancellous-bone

Pathogenetic studies of motor fluctuations in Parkinson’s diseasete advanced Parkinson’s disease. Since levodopa clearance from the general circulation was found to be similar in patients with wearing-off or on-off phenomena and those with a stable response to levodopa, peripheral pharmacokinetic factors are unlikely to be involved. Efficacy half-time for levodop

Employee

The case for and concerns about continuous dopamine stimulation in Parkinson’s diseaseluctations in response (“on-off”). This should be manageable with innovative delivery systems for the drugs. However further studies are required to determine if continuous dopaminergic stimulation will be complicated by increased levels of drug metabolites or down regulation of dopaminergic neurotr

jabber

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