Titlebook: Congenital Brain Malformations; Clinical and Surgica Khaled Fares AlAli,Hashim Talib Hashim Book 2024 The Editor(s) (if applicable) and The

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https://doi.org/10.1057/9781137426444ds, it can be defined as a head size smaller than average for age and sex. Either due to abnormalities in brain development hindering the brain from reaching its full size or sudden stoppage of brain growth for many reasons. Congenital microcephaly is present at birth, whereas postnatal microcephaly

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https://doi.org/10.1007/978-981-19-4617-2al overgrowth. The underlying etiologies allow the classification of megalencephaly into anatomic, related to mutations in signaling pathways governing neuronal growth and migration, and metabolic, caused by abnormal cellular metabolism. Patients can present with abnormal head circumference, mental

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https://doi.org/10.1007/978-981-19-4617-2aused by genetic causes or multifactorial causes. This malformation has many complications like seizures, abnormal development, mental retardation and paralysis. It may be associated with other malformations like microcephaly or hydrocephaly. The severity of the malformation can determine the signs

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https://doi.org/10.1057/9781137277619) in the brain and microcephaly (a few cases) that affects developing fetuses. It is an abnormality of cortical development associated with deficient neuronal migration (the process in which nerve cells move from their place of origin to their permanent location) during embryonic development between

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