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Titlebook: Conditional Mutagenesis: An Approach to Disease Models; Robert Feil,Daniel Metzger Book 2007 Springer-Verlag Berlin Heidelberg 2007 Chromo

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書目名稱Conditional Mutagenesis: An Approach to Disease Models
編輯Robert Feil,Daniel Metzger
視頻videohttp://file.papertrans.cn/236/235210/235210.mp4
概述Includes supplementary material:
叢書名稱Handbook of Experimental Pharmacology
圖書封面Titlebook: Conditional Mutagenesis: An Approach to Disease Models;  Robert Feil,Daniel Metzger Book 2007 Springer-Verlag Berlin Heidelberg 2007 Chromo
描述.Leading experts provide timely and comprehensive information on methods for conditional mutagenesis in the mouse (part 1) and their application to model human physiology and pathophysiology (part 2). It illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. Finally the book considers the development of new drugs to treat them. .
出版日期Book 2007
關(guān)鍵詞Chromosom; conditional mutagenesis; cre recombinase; drug development; gene knockout; genes; molecular mec
版次1
doihttps://doi.org/10.1007/978-3-540-35109-2
isbn_softcover978-3-642-07121-8
isbn_ebook978-3-540-35109-2Series ISSN 0171-2004 Series E-ISSN 1865-0325
issn_series 0171-2004
copyrightSpringer-Verlag Berlin Heidelberg 2007
The information of publication is updating

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Tetracycline-Controlled Genetic Switchesse. Trancriptional activation can be induced by activators termed tTA (Tet-Off) or rtTA (Tet-On) in the absence and presence of Tet, respectively. The Tet-Off and Tet-On systems are complementary, and the decision to choose one over the other depends on the particular experimental strategy. Both sys
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Novel Gene Switchesery as well as fundamental and applied research. This chapter provides a comprehensive overview of the different approaches for regulating gene activity and product protein formation at different biosynthetic levels, from genomic rearrangements over transcription and translation control to strategie
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Improved Embryonic Stem Cell Technologiesadvances, including tetraploid aggregation, new site-specific recombinases and RNAi, have enabled more sophisticated manipulation of the ES cell genome. For instance, it is now possible to control gene expression in both a temporally and spatially restricted manner. Such new technologies are answeri
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Gene Trap Mutagenesiso a powerful tool for dissecting the genetic causes of human disease and identifying potential targets for pharmaceutical intervention. With the recent sequencing of the human and mouse genomes, a large number of novel genes have been identified whose function in normal and disease physiology remain
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