Titlebook: Concepts in Biochemical Pharmacology; Part 1 Bernard B. Brodie,James R. Gillette,Helen S. Acker Book 1971 Springer-Verlag Berlin · Heidelbe

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Bernard B. Brodie,James R. Gillette,Helen S. Acker

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Book 1971 true discipline in its own right, and is no longer the handmaiden of organic chemistry and physiology. Instead it is an amalgam of all the biological sciences including biochemistry, biophysical chemistry, physiology, pathology and clinical medicine. In the volumes that make up Concepts in Bioche-

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https://doi.org/10.1007/978-3-319-63462-3 effects of protein-binding on drug distribution and hence on activity; Section B discusses the ways in which protein- binding can affect drug elimination and Section C attempts a quantitative analysis of the ways in which these various factors interact in drug kinetics.

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https://doi.org/10.1007/978-3-642-88510-5esent chapter will concentrate on these fundamental principles. For more detailed analysis of some individual drug groups, the interested reader is directed to excellent reviews by . (1961), . and . (1962), . and . (1965) and . and . (1966).

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Effect of Binding to Plasma Proteins on the Distribution, Activity and Elimination of Drugs effects of protein-binding on drug distribution and hence on activity; Section B discusses the ways in which protein- binding can affect drug elimination and Section C attempts a quantitative analysis of the ways in which these various factors interact in drug kinetics.

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