Titlebook: Concepts and Principles of Pharmacology; 100 Years of the Han James E. Barrett,Clive P. Page,Martin C. Michel Book 2019 Springer Nature Swi

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Monoclonal Antibodies: Past, Present and Future,study population, route/s of administration, starting dose, study design and the potential difference in pharmacokinetics in healthy subjects compared to patients expressing the target antigen..Of the ever-increasing diversity of therapeutic indications for mAbs, we have concentrated on two that hav

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Ion Channel Pharmacology for Pain Modulation, study of ASIC or PIEZO channels in pain signaling is in an early stage, whereas antagonism of the purinergic P2X. channels has been reported to provide beneficial effects in chronic intractable cough. The present chapter covers these intriguing channels in great detail, highlighting their diverse m

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Mechanistic Image-Based Modelling: Concepts and Applications,mage-based modelling in pharmaceutical industry holds promise to further advance model-informed drug discovery and development and aids substantially in our understanding of drug pharmacokinetic, pharmacodynamic and ultimately de-risk drug development.

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The Microbiome and Its Potential for Pharmacology,iew we briefly discuss the nature of human microbial ecosystems and with pathologies and biological processes linked to the microbiome. We then review emerging computational metagenomic, metabolomic, and wet lab techniques researchers are using today to learn about the roles host-microbial interacti

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Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems PharmaME-Tox. Human MPS experimental models have been developed to address the relatively low concordance of human disease and ADME-Tox with engineered, experimental animal models of disease. The integration of the QSP paradigm with the use of human MPS has the potential to enhance the process of drug dis

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The Future of Clinical Trial Design: The Transition from Hard Endpoints to Value-Based Endpoints,disease at home or at work. Furthermore, they will measure the subjective experience of subjects in relation to other objective measurements. Ideally, the endpoints are suitable for individual assessment of the effect of an intervention. The value-based clinical trial of the future will have a low b

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Pharmacoepidemiology,The methods can be exposure or disease-based cohorts or event-driven case-based studies, tailored to the specific questions to be answered. They rely on scrupulous analysis and execution of impeccable methodology, to ensure the most reliable results possible..Pharmacoepidemiology requires knowledge