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Titlebook: Computational Systems Biology; Reneé Ireton,Kristina Montgomery,Jason McDermott Book 2009 Humana Press 2009 Analysis.algorithms.bioinforma

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書目名稱Computational Systems Biology
編輯Reneé Ireton,Kristina Montgomery,Jason McDermott
視頻videohttp://file.papertrans.cn/234/233166/233166.mp4
概述Presents a broad range of topics related to computational systems biology, including mechanistic modeling, high-throughput data analysis, biological network analysis and data representation and manage
叢書名稱Methods in Molecular Biology
圖書封面Titlebook: Computational Systems Biology;  Reneé Ireton,Kristina Montgomery,Jason McDermott Book 2009 Humana Press 2009 Analysis.algorithms.bioinforma
描述Computational systems biology is the term that we use to describe computational methods to identify, infer, model, and store relationships between the molecules, pathways, and cells (‘‘systems’’) involved in a living organism. Based on this definition, the field of computational systems biology has been in existence for some time. However, the recent confluence of high-throughput methodology for biological data gathering,genome-scalesequencing,andcomputationalprocessingpowerhasdrivena reinvention and expansion of this field. The expansions include not only modeling of small metabolic (1–3) and signaling systems (2, 4) but also modeling of the relati- ships between biological components in very large systems, including whole cells and organisms (5–15). Generally, these models provide a general overview of one or more aspects of these systems and leave the determination of details to experimentalists focused on smaller subsystems. The promise of such approaches is that they will elucidate patterns, relationships, and general features, which are not evident from examining specific components or subsystems. These predictions are either interesting in and of themselves (e. g. , the iden
出版日期Book 2009
關(guān)鍵詞Analysis; algorithms; bioinformatics; evolution; genes; genome; modeling; molecular biology; Systems Biology
版次1
doihttps://doi.org/10.1007/978-1-59745-243-4
isbn_softcover978-1-4939-5644-9
isbn_ebook978-1-59745-243-4Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightHumana Press 2009
The information of publication is updating

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David B. Audretsch,Werner B?nte,Max Keilbachiptional regulation in higher eukaryotes, particularly in metazoans, could be an important factor contributing to their organismal complexity. Here we present an integrated approach where networks of co-expressed genes are combined with gene ontology–derived functional networks to discover clusters
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M. H. Bala Subrahmanya,Rumki Majumdarys to understand the intricate interplay between interactome and proteome. Ultimately, the combination of these sources of information will allow the prediction of interactions among proteins where only domain composition is known. Based on the currently available protein–protein interaction and dom
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International Studies in Entrepreneurshiptions. While being successful on specific data, the concept has never been tested on a large set of proteins. In this chapter we analyze the feasibility of the co-evolution principle for protein–protein interaction prediction through one of its derivatives, the correlated divergence model. Given two
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International Studies in Entrepreneurshipzation and evolution of biological systems. Data quality of experimental interactome maps can be assessed and improved by integrating multiple sources of evidence using machine learning methods. Here we describe the commonly used algorithms for predicting protein–protein interaction by genome data i
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David B. Audretsch,Werner B?nte,Max Keilbachseveral results from genome-wide analysis of transcriptional regulatory networks are available, they are limited to model organisms such as yeast ... and worm .... Beyond these networks, experiments on TRIs study only individual genes and proteins of specific interest. In this chapter, we present a
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Forest Assessment and Observation,r, detecting them in highly integrated biological networks requires a thorough understanding of the organization of these networks. In this chapter I argue that many biological networks are organized into many small, highly connected topologic modules that combine in a hierarchical manner into large
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