Titlebook: Computational Methods in Systems Biology; 10th International C David Gilbert,Monika Heiner Conference proceedings 2012 Springer-Verlag Berl

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Conference proceedings 2012 CMSB 2012, held in London, UK, during October 3-5, 2012. The 17 revised full papers and 8 flash posters presented together with the summaries of 3 invited papers were carefully reviewed and selected from 62 submissions. The papers cover the analysis of biological systems, networks, and data ranging

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Aaron M. Ellison,Manisha V. Patelensitivity Analysis of the metabolic model, which finds the inputs with the highest influence on the outputs of the model. We show that our methodology provides effective vision of the achievable synthetic strain landscape and a powerful design pipeline.

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Accounting for Mental Reference,o the parameter space of the biological system under investigation. The EPA framework is demonstrated through application to a novel example: T helper cell activation in the immune system in the presence of co-infection.

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Predicting Phenotype from Genotype through Automatically Composed Petri Netstterns and the resulting protein concentrations. Gene modules and allelic interference modules may represent effects of gene mutation and predict their pleiotropic consequences or uncover complex genotype/phenotype relationships. Forward and reverse engineered modules are fully compatible.