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Titlebook: Complement Therapeutics; John D. Lambris,V. Michael Holers,Daniel Ricklin Book 2013 Springer Science+Business Media New York 2013 infectio

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書目名稱Complement Therapeutics
編輯John D. Lambris,V. Michael Holers,Daniel Ricklin
視頻videohttp://file.papertrans.cn/232/231284/231284.mp4
概述Proceedings from the 5th International Complement Theraputics Conference.Part of the Aegean Conferences series.Incorporates cutting-edge research and showcases methods developed and perfected in the l
叢書名稱Advances in Experimental Medicine and Biology
圖書封面Titlebook: Complement Therapeutics;  John D. Lambris,V. Michael Holers,Daniel Ricklin Book 2013 Springer Science+Business Media New York 2013 infectio
描述.This book highlights progress and trends in the rapidly evolving field of complement-related drug discovery and spotlights examples of clinical applications. As an integral part of innate immunity and critical mediator in homeostatic and inflammatory processes, the human complement system has been identified as contributor to a large number of disorders including ocular, cardiovascular, metabolic, autoimmune, and inflammatory diseases as well as in ischemia/reperfusion injury, cancer and sepsis. In addition, complement is often involved in adverse immune reactions to biomaterials, cell and organ transplants or drug delivery systems. Although the complement cascade with its close to 50 extracellular protein targets has long been recognized as an attractive system for therapeutic modulation, the past few years have seen a particularly strong boost in interest. Fueled by novel research insight and the marketing of the first complement-targeted drugs, a plethora of highly creative treatment approaches and potent drug candidates have recently emerged and are currently evaluated in disease models and clinical trials..?.The chapters in this book cover a wide range of topics related to th
出版日期Book 2013
關(guān)鍵詞infectious diseases
版次1
doihttps://doi.org/10.1007/978-1-4614-4118-2
isbn_softcover978-1-4899-7823-3
isbn_ebook978-1-4614-4118-2Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightSpringer Science+Business Media New York 2013
The information of publication is updating

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https://doi.org/10.1057/9780230349414ex signaling mechanisms. Regulation of DAF expression may involve a direct or an indirect effect of at least the estrogen, progesterone, and corticosteroid regulatory pathways. DAF is exploited in multiple pathologic conditions by pathogens and viruses in chronic tissue infection processes. The bind
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Captivating Quanzhou Specialties,prevent the generation of BK but also reduce C1q-induced or microbial-ligand-induced inflammatory responses. Employing synthetic peptides and gC1qR deletion mutants, we confirmed previously predicted sites for C1q (residues 75–96) and HK (residues 204–218) and identified additional sites for both C1
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Janine O. Ilagan,Melissa S. Juricand (3) avoiding infectious complications or impairment of other important physiological functions of complement when using systemically active complement-blocking agents. This chapter will review data that address these challenges to therapeutic development, with a focus on the development of a nove
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Klaus B?hmer,Günter Meinardus,Walter SchemppPNH was an appropriate medical condition to develop and to investigate therapeutical complement inhibitors. Indeed, the first complement inhibitor eculizumab, a humanized anti-C5 monoclonal antibody, has been proven safe and effective for the treatment of PNH patients. Chronic treatment with eculizu
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