Titlebook: Complement Activation in Malaria Immunity and Pathogenesis; José A. Stoute Book 2018 Springer International Publishing AG, part of Springe

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Holger Dannenberg,Dirk Zupanciceficient in the receptors for C3a and C5a are fully susceptible to ECM. These results implicated C5b and the membrane attack complex (MAC) as the drivers of ECM pathogenesis. Indeed, treatment with anti-C9 antibody reduced mortality in ECM. The detection of C5a in the serum of C3-deficient mice sugg

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Holger Dannenberg,Dirk Zupancic low birth weight, and neurodevelopmental deficits. Together, these data indicate a critical role for complement in the pathophysiology of malaria in pregnancy and suggest that it is a target for drugs to reduce malaria-mediated adverse pregnancy outcomes.

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Interferons

nd how these mechanisms may translate into paradoxical enhancement of infection rather than protection. Finally, they also discuss the role of the mosquito complement system on immunity against the parasite.?.978-3-030-08412-7978-3-319-77258-5

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Role of Complement in Severe Malarial Anemia,alarial anemia (SMA). There are now considerable data that suggest that complement plays a role in the development of anemia during malaria infection by opsonization of uninfected erythrocytes with C3 fragments which can lead to phagocytosis of erythrocytes. The increased susceptibility to complemen

Eclampsia

Role of Complement in Cerebral Malaria,nt-mediated host defense offers little protection against malaria infection. What role then does complement play in malaria infection, particularly CM? Studies demonstrate that C5-deficient mice are highly resistant to experimental CM, the animal model for CM. Using complement-deficient mice, our la

Essential

Complement and Malaria in Pregnancy, birth outcomes including stillbirth, preterm birth, and fetal growth restriction. Inflammation at the maternal-fetal interface and dysregulated angiogenesis are thought to underlie malaria-associated adverse birth outcomes. Uniquely, the complement system, through its impact on both inflammatory an

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