Titlebook: Combination Cancer Therapy; Modulators and Poten Gary K. Schwartz Book 2005 Humana Press 2005 Chemotherapie.apoptosis.carcinoma.cell.leukem

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Role of Grain Boundaries in Sintering it infrequently results in improved survival—the end-point that probably matters most. Pharmacological modulation of any drug revolves around understanding those critical relationships between biochemical targets in the cell, and how we can exploit their underlying biology in a way that renders any

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Computer Simulation of Sintering Processesegulated by signals received from the environment (.). Signals may come from interactions with other cells or components of the extracellular matrix, or from binding of soluble signaling molecules to specific receptors at the cell membrane, thereby initiating different signaling pathways inside of t

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Pharmacological Modulation of Fluoropyrimidines, it infrequently results in improved survival—the end-point that probably matters most. Pharmacological modulation of any drug revolves around understanding those critical relationships between biochemical targets in the cell, and how we can exploit their underlying biology in a way that renders any

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Use of Animal Models to Evaluate Signal Transduction Inhibitors As Modulators of Cytotoxic Therapy,egulated by signals received from the environment (.). Signals may come from interactions with other cells or components of the extracellular matrix, or from binding of soluble signaling molecules to specific receptors at the cell membrane, thereby initiating different signaling pathways inside of t

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Targeting of the EGFR As a Modulator of Cancer Chemotherapy,ors. In human tumors, receptor overexpression correlates with a more aggressive clinical course. These observations suggest that the EGFR is a promising target for cancer therapy, and monoclonal antibodies directed at the ligand-binding extracellular domain and low molecular weight (MW) inhibitors o

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Cyclin-Dependent Kinase Inhibitors in Combination Chemotherapy, carcinogenesis. This novel class of anticancer therapeutics exploits these perturbations to achieve tumor-specific cytotoxicity. In the last several years, our understanding of cell-cycle regulation has improved with the emerging concepts of cell-cycle-mediated drug resistance and cell-cycle modula

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Carboxyamidotriazole, an Inhibitor of Nonvoltage-Operated Calcium Entry,ency have been made, improvement in cure rate for advanced-stage cancers remains unchanged. This sobering statistic has led investigators to search for novel targets and intervention combinations for the prevention and treatment of cancer. The advent of combination carboplatin/paclitaxel for the adj