Titlebook: Colorectal Cancer Liver Metastases; A Comprehensive Guid Mauro Monteiro Correia,Michael A. Choti,Go Wakabay Book 2020 Springer Nature Switz

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Diagnosis of Colorectal Liver Metastases,llow-up after the treatment of the primary. This diagnosis is based in clinical, laboratory, and radiological studies. This chapter will address the different circumstances of the diagnosis and the role of each of the present diagnostic tools.

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What Is the Impact of Positive Margins in the Liver?,or. Yet, more recent studies have challenged the oncologic impact of close or microscopically positive (R1) resection. This is particularly important to understand, as this is one factor which is potentially under the control of the surgeon.

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Defining Resectability of Colorectal Cancer Liver Metastases: Technical and Oncologic Perspectives,tes among patients with CRLM are warranted. Resectability of CRLM should be defined along three domains: from a medical standpoint, an oncologic standpoint, and finally a technical standpoint. Adherence to a stepwise protocol for preoperative evaluation of patients with CRLM is critical to ensure proper patient selection and to optimize outcomes.

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Anatomical, Physiological, and Kinetic Evaluation of the Future Liver Remnant of CRLM After Portal sary to understand PVE indication and FLR evaluation. In this chapter, we summarize how to evaluate FLR from anatomical, physiological, and kinetic aspects and we describe the effects and problems of PVE referring to previously published papers.

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The Biology of Colorectal Liver Metastases, the major cause of cancer-related mortality and continues to be a major challenge for clinicians and scientists. Developing earlier detection methods and more effective therapies requires understanding the complex mechanisms that drive colorectal cancer liver metastasis biology. However, due to the

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Molecular Biomarkers for the Management of Colorectal Cancer Liver Metastases,es such as tumor size and focality, primary colon cancer nodal status, disease-free interval, and serum CEA level. Given the high risk of recurrence even after margin-negative resection for CRLM, these variables have been used to guide patient selection, treatment decisions, risk stratification, and

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Role of Imaging in the Management of Patients with Potentially Resectable CRLM,metastases (CRLM). Modalities such as ultrasound (US), multidetector computed tomography (MDCT), magnetic resonance imaging (MRI), and positron emission tomography (PET) are used for CRLM and hepatic assessment. This chapter will discuss the current role of these imaging modalities in the management

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Staging Classifications of Colorectal Liver Metastases,ing liver resection, the most important variables were maximum size and number of CRLM, primary regional lymph node metastasis, and preoperative carcinoembryonic antigen level. In 2017, the eighth TNM cancer staging system of the Union for International Cancer Control and the American Joint Committe

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Prognostic Factors of Colorectal Cancer Liver Metastasis,at will influence their therapeutic approach..Our objective in this chapter is to discuss the prognostic characteristics of colorectal liver metastases considering the evolution of biological factors and multimodal treatments in addition to the classically studied factors..It was didactically divide